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Glycolipid A mimetics ? its chemo-enzymatic synthesis and immunological testing

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    COST

  • Call for proposals

    COST 2 (SMSM200232004)

  • Main participants

    Mikrobiologický ústav AV ČR, v. v. i.

  • Contest type

    VS - Public tender

  • Contract ID

Alternative language

  • Project name in Czech

    Deriváty glykolipidu A, jeho chemoenzymatická syntéza a imunologické testování

  • Annotation in Czech

    Budou připraveny nové prekursory glykolipidu A pomocí chemoenzymatických metod na bázi chitooligomerů a aminosacharidů. Nové deriváty glykolipidu A připravené dalšími členy mezinárodního konsorcia (WG) budou testovány na imunogenicitu a toxicitu. Předpok, ládaným výsledkem by mělo být glykomimetikum, které by byly použitelné v terapii septického šoku., ,

Scientific branches

  • R&D category

  • CEP classification - main branch

    CE - Biochemistry

  • CEP - secondary branch

    EC - Immunology

  • CEP - another secondary branch

    EI - Biotechnology and bionics

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>20801 - Environmental biotechnology<br>20802 - Bioremediation, diagnostic biotechnologies (DNA chips and biosensing devices) in environmental management<br>20803 - Environmental biotechnology related ethics<br>20901 - Industrial biotechnology<br>20902 - Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation<br>20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials<br>30102 - Immunology<br>30401 - Health-related biotechnology<br>30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)<br>30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])<br>30404 - Biomaterials (as related to medical implants, devices, sensors)<br>30405 - Medical biotechnology related ethics<br>40401 - Agricultural biotechnology and food biotechnology<br>40402 - GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming<br>40403 - Agricultural biotechnology related ethics

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    4 publikace v impaktovaných časopisech, příprava nových látek, vypracování původní metodiky testování, biologické testování

Solution timeline

  • Realization period - beginning

    Jan 1, 2002

  • Realization period - end

    Jan 1, 2003

  • Project status

    U - Finished project

  • Latest support payment

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP/2004/MSM/MSM4OC/U/N/2:1

  • Data delivery date

    Jun 16, 2004

Finance

  • Total approved costs

    1,131 thou. CZK

  • Public financial support

    726 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    405 thou. CZK