Characterization of metalloproteins important in cancer their interactions with DNA

Provider

Ministry of Education, Youth and Sports

Programme

COST

Call for proposals

COST 2 (SMSM200232004)

Main participants

Biofyzikální ústav AV ČR, v. v. i.

Contest type

VS - Public tender

Contract ID

—

Project name in Czech

Charakterizace metaloproteinů významných v rakovině a jejich interakce s DNA

Annotation in Czech

Charakterizace metaloproteinů významných v rakovině, zejména nádorového supresoru p53 a metalothioneinů. Bude zkoumána vazba p53 na lineární a nadšroubovicové DNA a navrženy nové metody anylýzy těchto proteinů.

R&D category

NV - Nonindustrial research (Applied research excluded Industrial research)

CEP classification - main branch

FB - Endocrinology, diabetology, metabolism, nutrition

CEP - secondary branch

FP - Other medical fields

CEP - another secondary branch

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

30106 - Anatomy and morphology (plant science to be 1.6)<br>30107 - Medicinal chemistry<br>30108 - Toxicology<br>30109 - Pathology<br>30202 - Endocrinology and metabolism (including diabetes, hormones)<br>30221 - Critical care medicine and Emergency medicine<br>30223 - Anaesthesiology<br>30224 - Radiology, nuclear medicine and medical imaging<br>30225 - Allergy<br>30226 - Rheumatology<br>30227 - Geriatrics and gerontology<br>30229 - Integrative and complementary medicine (alternative practice systems)<br>30230 - Other clinical medicine subjects<br>30302 - Epidemiology<br>30303 - Infectious Diseases<br>30307 - Nursing<br>30308 - Nutrition, Dietetics<br>30309 - Tropical medicine<br>30310 - Parasitology<br>30311 - Medical ethics<br>30312 - Substance abuse<br>30501 - Forensic science<br>30502 - Other medical science

Provider evaluation

V - Vynikající výsledky projektu (s mezinárodním významem atd.)

Project results evaluation

7 papers, 1 book chapter, 1 book. Electrochemical methods of protein analysis and new approaches in studies of DNA-protein interactions were proposed. It was found that zinc-containing tumor suppressor protein p53 binds preferentially to consensus seque

Realization period - beginning

Jan 1, 2002

Realization period - end

Jan 1, 2005

Project status

U - Finished project

Latest support payment

—

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data delivery code

CEP06-MSM-OC-U/04:2

Data delivery date

May 28, 2008

Total approved costs

3,290 thou. CZK

Public financial support

1,265 thou. CZK

Other public sources

0 thou. CZK

Non public and foreign sources

1,700 thou. CZK