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OC08006

Targeted cancer radiotherapy in preclinical experiment

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    COST

  • Call for proposals

    COST 6 (SMSM2008OC3)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    1146/2010-32

Alternative language

  • Project name in Czech

    Cílená radioterapie nádorů v preklinickém experimentu

  • Annotation in Czech

    Cílem projektu je získání nových teoretických poznatků o biologickém chování nově vyvíjených radiofarmak určených především pro diagnostiku a terapii nádorů a dále získání podkladů pro případné využití těchto potenciálních léčiv v klinické praxi.

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    FR - Pharmacology and apothecary chemistry

  • CEP - secondary branch

    FD - Oncology and haematology

  • CEP - another secondary branch

    CH - Nuclear and quantum chemistry, photo chemistry

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10402 - Inorganic and nuclear chemistry<br>30104 - Pharmacology and pharmacy<br>30204 - Oncology<br>30205 - Hematology

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    Radiolabelled derivatives of somatostatin, gastrin and bombesin have been described in terms of their biodistribution profiles in laboratory animals and transport mechanisms in the kidneys, which are dose-limiting organ in radiotherapy. Radiolabelling ofPAMAM dendrimers modified with DO3A-Py-Nox for binding of Lu-177, In-111 or Y-90 and biodistribution in laboratory rats were also determined.

Solution timeline

  • Realization period - beginning

    Jan 1, 2008

  • Realization period - end

    Dec 31, 2011

  • Project status

    U - Finished project

  • Latest support payment

    Feb 22, 2011

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP12-MSM-OC-U/01:1

  • Data delivery date

    Jul 12, 2012

Finance

  • Total approved costs

    4,900 thou. CZK

  • Public financial support

    2,800 thou. CZK

  • Other public sources

    2,100 thou. CZK

  • Non public and foreign sources

    0 thou. CZK