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OC09003

Porcine enzymes of biotransformation

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    COST

  • Call for proposals

    COST 7 (SMSM2009OC4)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    1682/2009-32

Alternative language

  • Project name in Czech

    Porcinní biotransformační enzymy

  • Annotation in Czech

    Cílem projektu je získat informace o podobnosti lidských a prasečích jaterních enzymů účastnících se biotransformace (metabolismu) cizorodých látek. Cíle bude dosaženo srovnáním aktivit CYP (CYP2E1 a CYP2A19 resp. CYP2A6) a mikrosomálních UGT a SULT.

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    CE - Biochemistry

  • CEP - secondary branch

    FR - Pharmacology and apothecary chemistry

  • CEP - another secondary branch

    GI - Farm animal breeding and farm animal pedigree breeding

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30104 - Pharmacology and pharmacy<br>40203 - Husbandry

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    1. Matal J, Tunková A, Šiller M, Anzenbacherová E, Anzenbacher P Isolation of two cytocchrome P450 forms, CYP2A19 and CYP1A, from pig liver microsemes. J Vet Pharmacol Ther. 32(5): 470 - 476. 2. Matal J, Matušková Z, Tunková A, Anzanbacher P Porcine CYP2A19, 2E1 and 1A2 froms are responsible for skatole biotransformation in the reconstituted system.

Solution timeline

  • Realization period - beginning

    Apr 1, 2009

  • Realization period - end

    Nov 30, 2009

  • Project status

    U - Finished project

  • Latest support payment

    Apr 22, 2009

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP10-MSM-OC-U/02:2

  • Data delivery date

    Jun 30, 2011

Finance

  • Total approved costs

    500 thou. CZK

  • Public financial support

    500 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK