Selective enzymatic oxidations and deracemizations of natural products and biomolecules
Public support
Provider
Ministry of Education, Youth and Sports
Programme
COST
Call for proposals
COST 7 (SMSM2009OC4)
Main participants
—
Contest type
VS - Public tender
Contract ID
1080/2011-320
Alternative language
Project name in Czech
Selektivní enzymové oxidace a deracemizace přírodních látek a biomolekul
Annotation in Czech
Vypracovat metody enzymových oxidativních a hydrolytických modifikací flavonoidů - s využitím pro separace jejich isomerů a diastereomerů a pro přípravu nových látek s chemoprotektivními a antioxidačními vlastnostmi.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
CC - Organic chemistry
CEP - secondary branch
CE - Biochemistry
CEP - another secondary branch
EI - Biotechnology and bionics
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10401 - Organic chemistry<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>20801 - Environmental biotechnology<br>20802 - Bioremediation, diagnostic biotechnologies (DNA chips and biosensing devices) in environmental management<br>20803 - Environmental biotechnology related ethics<br>20901 - Industrial biotechnology<br>20902 - Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation<br>20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials<br>30401 - Health-related biotechnology<br>30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)<br>30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])<br>30404 - Biomaterials (as related to medical implants, devices, sensors)<br>30405 - Medical biotechnology related ethics<br>40401 - Agricultural biotechnology and food biotechnology<br>40402 - GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming<br>40403 - Agricultural biotechnology related ethics
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
New chemoenzymatic method for separation of optically pure silybins and isosiiybins was developed. New enzymatic method for isoquercitrin preparation using fungal a-L-rhamnosidase was developed. Mechanism of antioxidative activity of silybin was elucidated by the isolation of the products of the oxidative attack - dimers. This mechanism was corroborated by molecular modeling.
Solution timeline
Realization period - beginning
Apr 1, 2009
Realization period - end
Jun 30, 2012
Project status
U - Finished project
Latest support payment
Feb 27, 2012
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP13-MSM-OC-U/01:1
Data delivery date
Jun 28, 2013
Finance
Total approved costs
1,760 thou. CZK
Public financial support
1,760 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK