Capillary leak syndrom. Importance for farmakokinetics and toxicokinetics of gentamicin.
Public support
Provider
Ministry of Education, Youth and Sports
Programme
COST
Call for proposals
COST 7 (SMSM2009OC4)
Main participants
—
Contest type
VS - Public tender
Contract ID
1 682/2009-32
Alternative language
Project name in Czech
Capillary leak syndrome a jeho význam pro kinetiku a dynamiku modelových léčiv.
Annotation in Czech
Validovaná a reprodukovatelná experimentální metoda navození capillary leak syndromu u malého laboratorního zvířete spolu s kriteriemi objektivního vyhodnocení typu syndromu a jeho závažnosti.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
FR - Pharmacology and apothecary chemistry
CEP - secondary branch
FP - Other medical fields
CEP - another secondary branch
ED - Physiology
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
30104 - Pharmacology and pharmacy<br>30105 - Physiology (including cytology)<br>30106 - Anatomy and morphology (plant science to be 1.6)<br>30107 - Medicinal chemistry<br>30108 - Toxicology<br>30109 - Pathology<br>30221 - Critical care medicine and Emergency medicine<br>30223 - Anaesthesiology<br>30224 - Radiology, nuclear medicine and medical imaging<br>30225 - Allergy<br>30226 - Rheumatology<br>30227 - Geriatrics and gerontology<br>30229 - Integrative and complementary medicine (alternative practice systems)<br>30230 - Other clinical medicine subjects<br>30307 - Nursing<br>30308 - Nutrition, Dietetics<br>30309 - Tropical medicine<br>30310 - Parasitology<br>30311 - Medical ethics<br>30312 - Substance abuse<br>30501 - Forensic science<br>30502 - Other medical science
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
Were established dose of lipopolysacharide and interleukin-2 to induce sepsis with capillary leakage. Volume of distribution was increased in experimental rats compared with controls, but the elimination halftime was shorter in LPSIL-2 rats and clearenceper kg was increasedin LPSIL-2 animals.
Solution timeline
Realization period - beginning
Apr 1, 2009
Realization period - end
May 31, 2009
Project status
U - Finished project
Latest support payment
Apr 22, 2009
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP10-MSM-OC-U/02:2
Data delivery date
Jun 30, 2011
Finance
Total approved costs
350 thou. CZK
Public financial support
350 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK