Short-term and long-term nonspecific changes in organisms exposed to high and low doses of nerve agents on cellular and molecular level
Public support
Provider
Ministry of Defence
Programme
Development - the development of attained operational capabilities of the Czech Armed Forces
Call for proposals
Rozvoj AČR 1 (SMO02008PR980)
Main participants
—
Contest type
VS - Public tender
Contract ID
0801 8 8020 R
Alternative language
Project name in Czech
RADSPEC - Krátkodobé a dlouhodobé nespecifické změny organismu exponovaného vysokým i nízkým dávkám nervově paralytických látek na buněčné a molekulární úrovni
Annotation in Czech
Cílem studie je ověření vhodnosti a perspetivy markerů, jako jsou fosfo-elk-1, fosfo-atf-2, fosfo-CREB, fosfo-p53 (aktivovaný v serinu 15), na modelu krys zasažených nervově paralytickou látkou (soman) ke stanovení jejich radiospecificity.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
KA - Militarism
CEP - secondary branch
BO - Biophysics
CEP - another secondary branch
FP - Other medical fields
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10610 - Biophysics<br>21100 - Other engineering and technologies<br>30106 - Anatomy and morphology (plant science to be 1.6)<br>30107 - Medicinal chemistry<br>30108 - Toxicology<br>30109 - Pathology<br>30221 - Critical care medicine and Emergency medicine<br>30223 - Anaesthesiology<br>30224 - Radiology, nuclear medicine and medical imaging<br>30225 - Allergy<br>30226 - Rheumatology<br>30227 - Geriatrics and gerontology<br>30229 - Integrative and complementary medicine (alternative practice systems)<br>30230 - Other clinical medicine subjects<br>30307 - Nursing<br>30308 - Nutrition, Dietetics<br>30309 - Tropical medicine<br>30310 - Parasitology<br>30311 - Medical ethics<br>30312 - Substance abuse<br>30501 - Forensic science<br>30502 - Other medical science
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
In RadSpec project, we compared ionizing radiation and nerve agents (soman, VX) effects on expression of activated MAPK and p53/p21 signalling pathways in rats in vivo in an attempt to find radiospecific biodozimetric markers. Among many results, p21 expression measured in peripheral mononuclear blood cells shows dose-dependent increase up to 3 Gy 4 h after irradiation and may find practical use.
Solution timeline
Realization period - beginning
Oct 1, 2008
Realization period - end
Dec 31, 2011
Project status
U - Finished project
Latest support payment
Feb 28, 2011
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP12-MO0-OV-U/01:1
Data delivery date
Jul 2, 2012
Finance
Total approved costs
2,196 thou. CZK
Public financial support
740 thou. CZK
Other public sources
1,456 thou. CZK
Non public and foreign sources
0 thou. CZK