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5 151 (0,172s) •

Project

Role of PI-3 iinase and Akt in regulation of the beta-catenin function in the colorectal adenocarcinoma cells (KJB5052302)

IEC-6 cells or human SW480 and SW620 colorectal cancer cells. Attention will be paid to a translocationof beta-catenin into the cell nucleus in the IEC-6 cells of the study is focused on a tentative role ...

EB - Genetika a molekulární biologie

  • 2003 - 2004
    • •
  • 1 443 tis. Kč
    • •
  • 851 tis. Kč
    • •
  • AV ČR
Project

Regulation of apoptosis induction by saturated and unsaturated fatty acids in pancreatic beta-cells a proteomic approach (GP14-00630P)

effects of SFAs and UFAs on beta-cell viability by employment the proteomic approach their suspected role in beta-cell apoptosis induction and inhibition by FAs by relevant in pathogenesis of type 2 diabetes. Satu...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2014 - 2019
    • •
  • 1 817 tis. Kč
    • •
  • 1 817 tis. Kč
    • •
  • GA ČR
Project

Significance of mitochondrial uncoupling in pancreatic beta cells for development of type-2 diabetes. (NR7917)

We'll study mitochondrial uncoupling of pancreatic beta-cells due to enhanced is to find blockers of the pathologically enhanced uncoupling of beta cell mitochondria that such antidiabetic drugs exist. Related to <...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2009
    • •
  • 12 765 tis. Kč
    • •
  • 8 453 tis. Kč
    • •
  • MZ
Project

Regulation of PKC beta 2 in malignant and differentiating colorectal adenocarcinoma cells (GP301/02/D159)

of the study will be focused on a regulation and function of PKC beta 2 in HT29 and Caco-2 carcinoma cells that possess the ability to differentiate accordingto expression epithelial cells of the large intestine. HT29 ...

EB - Genetika a molekulární biologie

  • 2002 - 2005
    • •
  • 745 tis. Kč
    • •
  • 745 tis. Kč
    • •
  • GA ČR
Project

Role of transforming growth factor-beta in regulation of proliferation, differentiation and apoptosis in prostate and colon cancer (GA204/07/0834)

factor-beta (PTGF-b), in cancer cells correlates with inhibition of proliferationBalance in regulation of cell proliferation, differentiation and cell death factor-beta (TGF-b) family have emerged as impo...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 3 144 tis. Kč
    • •
  • 3 144 tis. Kč
    • •
  • GA ČR
Project

Pancreatic beta cell-related genes and their role in the pathogenesis and treatment of monogenic diabetes (NV18-01-00078)

of the patients will include the functional testing of the beta cells or evaluation of immuneUp to 5% of the diabetes mellitus is caused by the monogenic defect of the beta cell function. Identification of the gen...

Endocrinology and metabolism (including diabetes, hormones)

  • 2018 - 2022
    • •
  • 11 275 tis. Kč
    • •
  • 11 275 tis. Kč
    • •
  • MZ
Project

Redox signaling essential for insulin secretion in pancreatic beta cells (GA24-10132S)

), we’ll study EndoC-βH1 cells and mitochondrial matrix metabolomics using beta-cell or EPAC2 pathways) and GPR40-receptor (FASIS, PKC pathways). Islet exosomes of beta-cell-specific NOX4KO-mice will be in...

Cell biology

  • 2024 - 2026
    • •
  • 10 596 tis. Kč
    • •
  • 10 299 tis. Kč
    • •
  • GA ČR
Project

Complex investigation of advanced beta-titanium alloys designed for biomedicine (GAP107/12/1025)

beta-Ti alloys for biomedical applications and the development of a new alloy. Biocompatibility and cell growth will be investigated employing both commercially available cell lines and primary osteogenic cells i...

JG - Hutnictví, kovové materiály

  • 2012 - 2015
    • •
  • 9 744 tis. Kč
    • •
  • 9 744 tis. Kč
    • •
  • GA ČR
Project

Study of beta -glucans of particular edible mushrooms (GA525/05/0273)

Edible mushrooms are a potential source of dietary fibre. Fungal cell walls contain besides chitin and other polysaccharides - beta-glucans. Beta-glucans from. The structural features of beta-glucans are important ...

GM - Potravinářství

  • 2005 - 2007
    • •
  • 2 393 tis. Kč
    • •
  • 2 393 tis. Kč
    • •
  • GA ČR
Project

Visualizing GPCR-G-protein-beta-arrestin supercomplexes in living cells using two-photon polarization microscopy (LTAIN19167)

To observe the presence and intracellular localization of GPCR-G-protein-beta-arrestin supercomplexes in order to determine their physiological role.......

Biophysics

  • 2020 - 2022
    • •
  • 4 754 tis. Kč
    • •
  • 4 754 tis. Kč
    • •
  • MŠMT
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