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794 (0,129s) •

Project

Correction of mutations underlying Fanconi anemia by prime editing - a novel therapeutical strategy for patients with inherited bone marrow failure syndromes (NW24-08-00388)

of the disease, which prevents using traditional editing strategies to correct the mutations. Prime editing is an advanced gene-editing method which employs distinct cellular. However, a successful correction of F...

Hematology

  • 2024 - 2027
    • •
  • 9 868 tis. Kč
    • •
  • 9 868 tis. Kč
    • •
  • MZ
Project

Developing CRISPR-PRIME for fruit development and seed dormancy studies (8J22FR026)

genome editing system in two major crops (tomatoes and rapeseed) by the mobility of ECR. A protocol for the CRISPR-PRIME genome editing method will be developed in France and rapeseed in the Czech Republic) and know-how (...

Plant sciences, botany

  • 2022 - 2023
    • •
  • 156 tis. Kč
    • •
  • 156 tis. Kč
    • •
  • MŠMT
Project

The function of FGFR2 cilia localization in glioblastoma pathogenesis (NW24-08-00364)

gene editing and rescue expresion to target cilia localization of FGFR2...

Oncology

  • 2024 - 2027
    • •
  • 14 710 tis. Kč
    • •
  • 14 710 tis. Kč
    • •
  • MZ
Project

Exploring non-canonical ORFs with functions in DNA damage repair (EH22_010/0008995)

The number of annotated genes has not changed significantly since the sequencing of the human genome 20 years ago. However, recent technological advances have revealed that our genome's protein-coding capacity is greater than previously thought, givin...

Genetics and heredity (medical genetics to be 3)

  • 2025 - 2028
    • •
  • 3 904 tis. Kč
    • •
  • 988 tis. Kč
    • •
  • MŠMT
Project

Staging the political exile. Czechoslovak politicians in London during WWII (GA18-02760S)

This project aims to explore the lives of Czechoslovak politicians living in London exile during the Second World War. Its prime focus of attention will be a collective monograph, an edition of Ivo Ducháček’s diaries interspersed wi...

History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

  • 2018 - 2022
    • •
  • 4 624 tis. Kč
    • •
  • 4 564 tis. Kč
    • •
  • GA ČR
Project

Thermoacoustic prime mover (GCP101/11/J019)

The project focuses on the fundamentals of thethermoacoustic energy conversion process in general, and improving athermoacoustic standing wave prime mover in particular. The project has the character of fundamental research and the expected ...

BJ - Termodynamika

  • 2011 - 2013
    • •
  • 5 664 tis. Kč
    • •
  • 5 664 tis. Kč
    • •
  • GA ČR
Project

Metal-induced resistance in pepper against Botrytis cinerea (GF25-19190L)

necrotroph Botrytis cinerea. We will test the hypothesis that defense priming by Zn those pathways that are becoming induced already after priming compared to those that become induced in Cu/Zn primed plants in response to...

Analytical chemistry

  • 2025 - 2028
    • •
  • 9 346 tis. Kč
    • •
  • 9 346 tis. Kč
    • •
  • GA ČR
Project

Study of NO(3) and NH(4) Ions Concentration Affect in Soil Solution on Course of Priming Effect and on Nitrogen Uptake and Utilization by Potato Plant (GA503/94/0993)

9B - 9

  • 1994 - 1996
    • •
  • 461 tis. Kč
    • •
  • 651 tis. Kč
    • •
  • GA ČR
Project

Distinct roles of IL-2 for antigen-primed CD8+ and CD4+ T cells a paradigm shift in T cell biology and implication for cancer immunotherapy (GA25-16348S)

Current immunology considers the IL-2 to be equally important for activated CD8+ and CD4+ T cells. This project aims to change the current paradigm in the field that IL-2 is a crucial cytokine for proliferation and survival of all antigen-primed<...

Immunology

  • 2025 - 2027
    • •
  • 8 997 tis. Kč
    • •
  • 8 997 tis. Kč
    • •
  • GA ČR
Project

Philosophy at the University of Prague around 1409 Matěj of Kníns Quodlibet as a Crossroads of European Medieval Knowledge (GA19-16793S)

of editions and analyses, the proposed project will map the doctrines present...

Theology

  • 2019 - 2022
    • •
  • 4 263 tis. Kč
    • •
  • 4 263 tis. Kč
    • •
  • GA ČR
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