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11 (0,122s) •

Project

IMMUNOMODULATORY EFFECTS OF TICK CYSTATINS (KJB500960702)

. Cysteine protease inhibitors (cystatins) of parasitic nematodes are well-described cystatins were found to play important role during tick feeding. Tick probably affects the host immune system by production of cystatins, ...

EC - Imunologie

  • 2007 - 2009
    • •
  • 1 350 tis. Kč
    • •
  • 1 350 tis. Kč
    • •
  • AV ČR
Project

Using of cystatin C determination in the group of patiens with neurodegenerative disease (NF7480)

This project is covered on verification (or refutation) of hypothesis about application of the cystatin C delimitations in CSF (serum) for the diagnostic (alternatively the prediction for the liability of origin) of the neurodegenerative dis...

FH - Neurologie, neurochirurgie, neurovědy

  • 2003 - 2005
    • •
  • 208 tis. Kč
    • •
  • 203 tis. Kč
    • •
  • MZ
Project

Effect of tick saliva cystatins on Th9 cells and the development of experimental asthma (GCP302/11/J029)

. In our pilot experiments we have shown that Ixodes ricinus tick saliva and cystatin of allergic asthma, the anti-asthmatic effect of tick cystatin has been proved. The main cystatins at molecular level and characterise th...

EC - Imunologie

  • 2011 - 2015
    • •
  • 4 824 tis. Kč
    • •
  • 4 824 tis. Kč
    • •
  • GA ČR
Project

The effect of tick salivary molecules on replication of tick-borne encephalitis virus in innate immunity cells (GA14-25799S)

is to understand how tick saliva and tick cystatins promote viral replication in cells the mechanism of this promotion, IFN-dependent and IFN-independent saliva/tick cystatin, and identification of proteins interacting with tick

EC - Imunologie

  • 2014 - 2016
    • •
  • 5 904 tis. Kč
    • •
  • 5 904 tis. Kč
    • •
  • GA ČR
Project

The functional characterization of tick salivary immunomodulators belonging to the Iristatin family (GA19-07247S)

, with immunomodulatory effects in vertebrate hosts. Iristatin is a secreted cystatin family member recruitment in an animal model of inflammation. We hypothesize that tick cystatins feeding by regulating several, redundant host imm...

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 11 674 tis. Kč
    • •
  • 11 380 tis. Kč
    • •
  • GA ČR
Project

Monitoring of serum cystatin C, IGFBP-3 and plasma DNA as a marker of organ impairment (NK6447)

Analysis and evaluation of the novel biochemical parametres for determination of hepatocytes metabolic function in transplant patients (lidocaine test, IGFBP-3, aminoacids). Analysis and evaluation of the novel biochemical parametres for determinatio...

FP - Ostatní lékařské obory

  • 2001 - 2003
    • •
  • 1 086 tis. Kč
    • •
  • 1 083 tis. Kč
    • •
  • MZ
Project

Myxozoan cystatins and fish host cathepsins Revealing potential crosstalk during infection (GA21-16565S)

cystatins expressed by the myxozoan parasite Sphaerospora molnari and the candidate assays. RNAi silencing of parasite cystatins and their co-immunolocalization with recombinant parasite cystatins will validate the potenti...

Biochemistry and molecular biology

  • 2021 - 2024
    • •
  • 6 606 tis. Kč
    • •
  • 6 606 tis. Kč
    • •
  • GA ČR
Project

Characterization of the abundant and functionally important molecules from the excretory-secretory products of Trichinella spiralis/Trichinella pseudospiralis L1 larvae and their use in diagnosis of trichinelosis. (LH12096)

From the point of view of basic research the project is focused on unknown aspects of T. pseudospiralis biology (which is less studied species compare to T. spiralis) by using the tools of functional proteomics and on molecular-taxonomy together with...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2012 - 2014
    • •
  • 4 092 tis. Kč
    • •
  • 3 582 tis. Kč
    • •
  • MŠMT
Project

Peptidases in the gut of the hard tick Ixodes ricinus characterization and potential for vector-control (GA206/06/0865)

Hemoglobin digestion in ticks is a critical process for tick survival for two main reasons: (1) Blood-meal digestion provides primary energy resources for tick development and egg production; (2) Hemoglobin fragmentation results in formation of pepti...

ED - Fyziologie

  • 2006 - 2008
    • •
  • 4 323 tis. Kč
    • •
  • 4 323 tis. Kč
    • •
  • GA ČR
Project

Inhibitors of cysteine proteases crucial for myxozoan pathogenicity and their interaction with the fish host (LTAUSA17201)

of evolution and functional diversification of cystatin superfamily in cnidarians, one...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2017 - 2021
    • •
  • 5 557 tis. Kč
    • •
  • 5 557 tis. Kč
    • •
  • MŠMT
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