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4 929 (0,112s) •

Project

Genetic bases of combined deficiency of oxidative phosphorylation complexes (NT13114)

Mitochondrial diseases caused by deficiency of one or several OXPHOS complexes represent a heterogeneous group of severe metabolic disorders caused by mutation in mtDNA or >100 nuclear genes. In group of 57 patients with combine...

FG - Pediatrie

  • 2012 - 2015
    • •
  • 9 698 tis. Kč
    • •
  • 9 650 tis. Kč
    • •
  • MZ
Project

MitoChip microarray for mitochindrial gene expression analysis and its application for study of nuclear defects of oxidative phosphorylation (NR8069)

Deficiencies of oxidative phosphorylation (OXPHOS) form important group of the OXPHOS deficiencies results from mutation of nuclear encoded mitochondrial genes with OXPHOS deficiencies. The object...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 6 198 tis. Kč
    • •
  • 6 060 tis. Kč
    • •
  • MZ
Project

Metabolic pathways of oxidative stress resistance in endothelial cells (GA22-34507S)

of OXPHOS, autophagy and FAO deficiency (and their combinations). Hereby we will map. Previously, we and collaborators demonstrated that oxidative phosphorylation (OXPHOS are metabolically linked, we hypothesize t...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 9 651 tis. Kč
    • •
  • 9 651 tis. Kč
    • •
  • GA ČR
Project

Targeting mitochondrial metabolism in pancreatic cancer therapy (GJ20-11724Y)

link between downregulated mitochondrial oxidative phosphorylation (OXPHOS is inactivated in about half of PC, we will evaluate the significance of SMAD4 deficiency in OXPHOS remodelling and metastatic potential. We will d...

Cell biology

  • 2020 - 2022
    • •
  • 6 300 tis. Kč
    • •
  • 6 300 tis. Kč
    • •
  • GA ČR
Project

Genetice and metabolic consequences ofinherited disorders of mitochondrial ATFase. (NE6533)

molecular mechanism responsible for the novel selective ATPase deficiency....

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 4 947 tis. Kč
    • •
  • 3 091 tis. Kč
    • •
  • MZ
Project

Ketogenic diet as a treatment for inborn defects of ATP synthase (NU21-07-00550)

of metabolism but largely lack treatments and have poor outcomes. ATP synthase deficiencies of the structural subunits. While less frequent than mutations in other OXPHOS complexes deficiency. Intriguingly, it not only imp...

Biochemistry and molecular biology

  • 2021 - 2025
    • •
  • 9 665 tis. Kč
    • •
  • 9 665 tis. Kč
    • •
  • MZ
Project

Rearrangement of cellular metabolism triggered by impairment of oxidative phosphorylation (GA21-18993S)

Mitochondria play an important role in ATP production and cellular homeostasis by provision of intermediates for biosynthetic pathways. In humans, the defects of oxidative phosphorylation (OXPHOS) lead to severe mitochondrial diseases, affec...

Endocrinology and metabolism (including diabetes, hormones)

  • 2021 - 2024
    • •
  • 7 137 tis. Kč
    • •
  • 7 137 tis. Kč
    • •
  • GA ČR
Project

The mitochondrial genome and oxidative phosphorylation system in metabolic syndrome (OC08017)

Mitochondrial oxidative phosphorylation (OXPHOS) provides most of energy in mammalian cells and tissues. OXPHOS system is uniquely encoded by both nuclear and mitochondrial genes. Dysfunction of OXPHOS are known to cause nu...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2008 - 2011
    • •
  • 1 706 tis. Kč
    • •
  • 1 706 tis. Kč
    • •
  • MŠMT
Project

The role of cytochrome c oxidase subunit COX6B isoforms in regulation of mitochondrial function in health and disease (GA22-21082S)

phosphorylation (OXPHOS) system responsible for ATP production in mammalian cells. Expression of tissue-specific isoforms of COX subunits represents a crucial mechanism of OXPHOS phenomenon of COX6B isoform exchange and its effect ...

Cell biology

  • 2022 - 2025
    • •
  • 7 050 tis. Kč
    • •
  • 7 050 tis. Kč
    • •
  • GA ČR
Project

Supramolecular assemblies in structural organization of inner mitochondrial membrane (GPP303/10/P227)

Recently, our understanding of oxidative phosphorylation (OXPHOS) complexes sufficient evidence for existence of OXPHOS supercomplexes in mammals, the mechanism project is to determine factors involved in association of mammalian

ED - Fyziologie

  • 2010 - 2014
    • •
  • 2 015 tis. Kč
    • •
  • 2 015 tis. Kč
    • •
  • GA ČR
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