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55 (0,193s) •

Project

Unified Bioinspired Total Syntheses of Complex Indolodiketopiperazine Alkaloid-Terpene Hybrid Natural Products and Their Analogs (GA22-32466S)

Bacterial terpenoid alkaloids, such as the hexa- or heptacyclic drimentines cationic terpenoid polyene cyclizations for precursors containing Lewis- or Brønsted-basic functionality in the alkaloid core. This approa...

Organic chemistry

  • 2022 - 2024
    • •
  • 5 477 tis. Kč
    • •
  • 4 794 tis. Kč
    • •
  • GA ČR
Project

Gels Produced Through Supramolecular Self-Assembly for Medicinal Chemistry Applications (LD13057)

The objective of the project consists in designing derivatives of selected plant products, phytosterols and terpenoids, able to form novel compounds phytosterols and terpenoids of betuline type. (2) Designing and synthesizing conjug...

CC - Organická chemie

  • 2013 - 2016
    • •
  • 1 692 tis. Kč
    • •
  • 1 692 tis. Kč
    • •
  • MŠMT
Project

Plant sources of minor benzophenanthridine alkaloids and study of their interaction with DNA (GA525/08/0819)

Benzo[c]phenathridine alkaloids display many significant biological effects focused on the study of alkaloid intracelular location referred the possibility to use DNA probes. Because the content of these alkaloids in plants...

GC - Pěstování rostlin, osevní postupy

  • 2008 - 2010
    • •
  • 2 944 tis. Kč
    • •
  • 2 944 tis. Kč
    • •
  • GA ČR
Project

Production of ergot alkaloid during the interaction of rye plant (Secale cereale) with fungus Claviceps purpurea (GAP501/12/0597)

. Infection of flowers initiates fungal sexual life cycle and synthesis of ergot alkaloids. Ergot alkaloids are used for preparation of various kind of therapeutics or change spectra of produced alkaloids by overexpression ...

EI - Biotechnologie a bionika

  • 2012 - 2015
    • •
  • 7 140 tis. Kč
    • •
  • 6 840 tis. Kč
    • •
  • GA ČR
Project

Functionalization of piperidine moiety of ergoline skeleton of ergot alkaloids and their oligomerization - ways to better drug targetting (1P05OC073)

new attitudes to modification of ergot alkaloids (EA) mainly by functionalization of D-circle of ergoline skeleton...

CC - Organická chemie

  • 2005 - 2007
    • •
  • 1 283 tis. Kč
    • •
  • 893 tis. Kč
    • •
  • MŠMT
Project

Examination of safety of the alkaloids from Macleaya cordata by study their interactions with DNA using modern analytical tools (GPP503/11/P312)

for study of benzo[c]phenanthridine and protopine alkaloids. The newly developed methods and techniques will be applied for sensitive analysis of the alkaloids in extracts-covalent interactions and covalent binding of the alkal...

GM - Potravinářství

  • 2011 - 2013
    • •
  • 1 992 tis. Kč
    • •
  • 1 992 tis. Kč
    • •
  • GA ČR
Project

Production of ergot alkaloids by parasitic and endophytic fungi (OC 835.30)

Screening for endophyte infected Czech ecotypes of agriculturally important grasses and analysis of toxic compounds produced by these endophytes. Analysis of ergot alkaloids in parasitic isolates of Claviceps. Molecular taxonomy of clavicipi...

EE - Mikrobiologie, virologie

  • 1999 - 2002
    • •
  • 3 625 tis. Kč
    • •
  • 1 250 tis. Kč
    • •
  • MŠMT
Project

Modification of D-ring of ergot alkaloids and preparation of their oligomers (IAA4020901)

The project deals with modification of the D-ring of ergot alkaloids, namely, introduction of additional double bond(s) using Polonovski reaction and/or Potier reaction of rgot alkaloids will be prepared using appropriate spacers or...

CC - Organická chemie

  • 1999 - 2002
    • •
  • 2 403 tis. Kč
    • •
  • 1 688 tis. Kč
    • •
  • AV ČR
Project

Polymorphism of peptide ergot alkaloids (GA203/00/D095)

The presented grant project is focused on relationship between structural and physical properties of various crystal forms of ergot alkaloids. Suitable conditions (influence of the temperature and solvent used) for various polymorphic phases...

CE - Biochemie

  • 2000 - 2003
    • •
  • 1 282 tis. Kč
    • •
  • 585 tis. Kč
    • •
  • GA ČR
Project

Benzophenanthridine alkaloids - study of their effects on cellular and molecular level (LH12176)

The aim of the project is to study benzophenanthridine alkaloids from the selected plant species in cooperation with chinese partner. The first aim is obtaining these alkaloids in sufficient amount. This assumes analysis of selected...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 3 007 tis. Kč
    • •
  • 3 007 tis. Kč
    • •
  • MŠMT
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