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13 645 (0,109s) •

Project

Involvement of nuclear Vinculin in ubiquitin relay of proteasomes during early meiotic events. (GA18-19714S)

and they undergo dramatic motions, finally stabilized by synaptonemal complexes. The ubiquitin-proteasome system (UPS) is a key regulators of cellular proteostasis. It is implicated in prophase I nuclei revealed the promin...

Cell biology

  • 2018 - 2022
    • •
  • 9 515 tis. Kč
    • •
  • 8 543 tis. Kč
    • •
  • GA ČR
Project

The role of SCF-FBXO28 ubiquitin ligase in cancer progression (GA18-27408S)

The tight control of the ubiquitin-proteasome system is accomplished by the specific selection of unneeded proteins which is dictated by E3 ubiquitin ligases. We will study this process in the context of cancer pro...

Cell biology

  • 2018 - 2022
    • •
  • 8 559 tis. Kč
    • •
  • 7 833 tis. Kč
    • •
  • GA ČR
Project

The possibilities to affect the negative protein balance in severe illness - the effect of proteasome inhibitors (GA303/03/1512)

demonstrates, that the stimulation of ubiquitin-proteasome system is the main cause information concerning the effect of proteasome inhibitors on protein and amino acid. Specific aims of the project are a) to sele...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
    • •
  • 2 862 tis. Kč
    • •
  • 2 862 tis. Kč
    • •
  • GA ČR
Project

The role of endosomal-lysosomal system in the pathogenesis of neurodegenerative disorders. (MEB060812)

This project is focused on the enlargement of previous cooperation in the field of prion diseases and other neurodegenerative disorders. Recent studies showed that the intensity of immunostaining for ubiquitin, proteasomal subunits,...

FH - Neurologie, neurochirurgie, neurovědy

  • 2008 - 2009
    • •
  • 37 tis. Kč
    • •
  • 37 tis. Kč
    • •
  • MŠMT
Project

Clinically relevant substrates of proteasome degradation in MDS. (NU21-08-00312)

category represents MDS with deletion of chromosome 5q. A prototype of proteasome (AZA). The mechanism how proteasome inhibitors function as oncotherapy involves inhibition of cullin-RING Ligases that target proteins quite specific...

Biochemistry and molecular biology

  • 2021 - 2024
    • •
  • 12 919 tis. Kč
    • •
  • 12 919 tis. Kč
    • •
  • MZ
Project

Identification and structural characterization of novel NPL4 inhibitors and insight into its mode of action (GA20-28685S)

Inhibition of protein degradation via ubiquitin-proteasome system is promising approach to treat cancer as documented by activity of bortezomib against multiple myeloma, however, resistance and limited activity urges for ne...

Cell biology

  • 2020 - 2022
    • •
  • 7 677 tis. Kč
    • •
  • 7 677 tis. Kč
    • •
  • GA ČR
Project

Molecular and cellular consequences of p53 manipulation using heat shock protein inhibitors and E3-ligases. (GA301/08/1468)

The level of p53 in normal cells is tightly regulated via induced degradation through the ubiquitin/proteasome system. MDM2 is major regulator of wild-type p53 degradation, although other ubiquitin ligases have bee...

FD - Onkologie a hematologie

  • 2008 - 2010
    • •
  • 3 063 tis. Kč
    • •
  • 2 925 tis. Kč
    • •
  • GA ČR
Project

The Role of Skp1-Cullin1-F-box Complex in Protein Ubiquitination and Degradation during Bovine Preimplantation Development (GP13-24730P)

is the ubiquitin-proteasome pathway. In the proposed project, I will focus on the role of one of two basic subtypes of ubiquitin-ligases; SCF (Skp1-Cul1-Fbox) complex; during......

EB - Genetika a molekulární biologie

  • 2013 - 2018
    • •
  • 2 709 tis. Kč
    • •
  • 2 709 tis. Kč
    • •
  • GA ČR
Project

The roles of phosphorylation and glucose sensing/signaling in the degradation of a yeast Saccharomyces cerevisiae proteins (GA204/02/1240)

The mechanism of selective, ubiquitin-dependent proteolytic degradation of two yeast model proteins, e.g., the Gal2p transport protein mediating specific galactose and how phosphorylation of Gal2p influences its ubiquitination and p...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 2 946 tis. Kč
    • •
  • 1 382 tis. Kč
    • •
  • GA ČR
Project

Targeted protein degradation in plant hormone cytokinin responses (7AMB17AT027)

(1) Generation of new mutant lines. The CRISPR/Cas9 system for targeted-wide analysis of the effects of disturbance in proteasome-dependent signaling lines with disrupted proteasome or cytokinin homeostasis. We will focus o...

CE - Biochemie

  • 2017 - 2018
    • •
  • 175 tis. Kč
    • •
  • 175 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 13 645