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431 (0,222s) •

Project

Transcriptional silencing of retroviral vectors during their integration into the host genome (GP301/09/P667)

The transcriptional silencing of retroviral vectors represents major of silencing differs among retroviral vectors of different origin. ASLV-based vectors in gene therapy. Silencing of retroviral ...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 1 500 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • GA ČR
Project

The effect of mutations and morphogenetic differences in matrix proteins on assembly and transport of retroviral capsids (GA203/98/P151)

Matrix protein (MA) of Mason-Pfizer monkey virus (M-PMV), which is the prototype of the type D retroviruses, plays a critical role in retroviral replication will be cloned into bacterial expression vector. The conditions for express...

CE - Biochemie

  • 1998 - 2000
    • •
  • 822 tis. Kč
    • •
  • 703 tis. Kč
    • •
  • GA ČR
Project

RNA interference applications in chickens (GA523/04/0569)

pseudotyped and pantropized retroviral vectors bearing the RNA hairpin casette.) in the chicken model. First, we would like to establish replication-competent retroviral vectors bearing the RNAi hairpin casette fo...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 2004 - 2006
    • •
  • 3 153 tis. Kč
    • •
  • 3 153 tis. Kč
    • •
  • GA ČR
Project

Improvement of the long-term expression and anti-methylation protection of RSV based retroviral vectors (IAA5052207)

repeats (LTR), is critical. RSV-based vectors are inactivated as well, being poorly CpG island sequence and creation of RSV-based vectors suitable for mammalian cells......

EE - Mikrobiologie, virologie

  • 2002 - 2004
    • •
  • 1 743 tis. Kč
    • •
  • 1 646 tis. Kč
    • •
  • AV ČR
Project

Mistargeting of somatic hypermutation and its role in B cell genome instability (GA15-24776S)

on retroviral vectors bearing our specially designed fluorescence marker (GFP7a), which loses its fluorescence as a result of SHM activity in the cell. Our vectors......

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 4 771 tis. Kč
    • •
  • 4 771 tis. Kč
    • •
  • GA ČR
Project

Avian Sarcoma and Leukosis Virus-based Vectors and Their Potential for Transgenesis in Chicken (GAP502/11/2207)

Retroviruses are important tools as gene delivery vectors for transgenesis. Among retroviruses, there are several reasons for the use of ASLV-based vectors as vectors for transgenesis and even for gene therapy with minimum ...

EB - Genetika a molekulární biologie

  • 2011 - 2015
    • •
  • 5 864 tis. Kč
    • •
  • 5 864 tis. Kč
    • •
  • GA ČR
Project

Chicken polymorphisms in retroviral receptors and their potential for cross-species transmission (GA13-30983S)

pseudotypes carrying reporter and different retroviral glycoproteins, we will correlate will profit from our recent experience with pseudotyped vectors derived from avian......

EB - Genetika a molekulární biologie

  • 2013 - 2017
    • •
  • 5 930 tis. Kč
    • •
  • 5 930 tis. Kč
    • •
  • GA ČR
Project

Drug resistance gene transfer into hematopoietic cells for protection against toxic and mutagenic effects of chemoterapy. (NC5727)

The retroviral vector-mediated transfer of drug resistance genes into hematopoietic cells will be optimized. Expression of the drug resistance genes will protect hematopoietic cells against toxic and mutagenic side effects of antitu...

FD - Onkologie a hematologie

  • 1999 - 2001
    • •
  • 5 455 tis. Kč
    • •
  • 5 433 tis. Kč
    • •
  • MZ
Project

Epigenomics of retroviral integration (GA14-34873S)

Genetic information is interpreted by epigenetic marks, DNA methylation and modification of histone tails, which control the transcriptional activity of genes and higher-order genome structures. Retroviruses integrated into the host genome are tightl...

EB - Genetika a molekulární biologie

  • 2014 - 2018
    • •
  • 5 836 tis. Kč
    • •
  • 5 836 tis. Kč
    • •
  • GA ČR
Project

Interactions of syncytins with specific cell receptors (GA17-14356S)

fusion instead of cell-to-cell fusion. We plan to prepare infectious retroviral vectors pseudotyped with syncytins and examinate the susceptibility of cells equipped......

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 7 524 tis. Kč
    • •
  • 6 717 tis. Kč
    • •
  • GA ČR
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