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7 111 (0,101s) •

Project

Gene expression profiling and functional characterization of glial cell subpopulations following ischemic brain injury (GA13-02154S)

subpopulations based on single cell gene expression profiling followed by their functional with resolution down to the single cell. The single cell expression profiling platform...

EB - Genetika a molekulární biologie

  • 2013 - 2016
    • •
  • 10 720 tis. Kč
    • •
  • 10 720 tis. Kč
    • •
  • GA ČR
Project

Cellular Expression Signatures in Idiopathic Pulmonary Fibrosis (ME10052)

1. Molecular characterization of single fibrocyte cells from dissociated fixed tissue collected from the lung of IPF patients. 2. Test presence of the circulating fibroblast cells in peripheral blood and explore their poten...

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 3 408 tis. Kč
    • •
  • 3 408 tis. Kč
    • •
  • MŠMT
Project

*R and D of certified technologie isolation of DNA from histopatologic material (FR-TI1/328)

for DNA purification from single cells microdissected from cytological to isolate single cells from microscopic slides without their losses and contamination purification steps and successful genetic profiling...

EB - Genetika a molekulární biologie

  • 2009 - 2012
    • •
  • 41 294 tis. Kč
    • •
  • 32 383 tis. Kč
    • •
  • MPO
Project

Specific metastatic site prediction due to the expression of "homing" factors in circulating tumor cells in experimental metastatic models (ME10045)

mice will be labelled by green fluorescent protein (GFP). Single cell gene for new cancer treatment strategies. Single cell gene expression will be analyzedProject is going to characterize gene expression prof...

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 3 063 tis. Kč
    • •
  • 3 063 tis. Kč
    • •
  • MŠMT
Project

Glial cells- the key players in the progression of amyotrophic lateral sclerosis (GA19-02046S)

to the single glial cell. The SC expression profiling combined with the data mining. A powerful high throughput single cell (SC) sequencing platform will be used to discover subpopulations within each gli...

Neurosciences (including psychophysiology)

  • 2019 - 2023
    • •
  • 9 950 tis. Kč
    • •
  • 9 734 tis. Kč
    • •
  • GA ČR
Project

Properties of horizontal mitochondrial transfer in cancer (GJ18-24753Y)

, protein) on single-cell and bulk level to correlate mtDNA transfer with gene expression profile focusing on respiration, cell cycle, intercellular-communication in the form of mitochondrial DNA (mtDNA). Cell<...

Cell biology

  • 2018 - 2022
    • •
  • 5 898 tis. Kč
    • •
  • 5 898 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of proliferation during tumor progression and wound healing studied by profiling on single cell level (GA17-24441S)

variability in modern diagnostic and research. Recently introduced single cell analysis this limitation in data interpretation. Our institute has a long-term tradition in single cell is to determine similarities a...

EB - Genetika a molekulární biologie

  • 2017 - 2020
    • •
  • 7 236 tis. Kč
    • •
  • 7 236 tis. Kč
    • •
  • GA ČR
Project

Renewal and modernization of the national infrastructure for translational medicine EATRIS-CZ (EH23_015/0008208)

and high resolution, equipment for genomic single-cell analysis, technology for genomic and/or proteomic profiling of cells in situ, respectively in a tissue context. 2. Sustainable spectrometer with high sensitiv...

Biochemistry and molecular biology

  • 2024 - 2026
    • •
  • 134 688 tis. Kč
    • •
  • 34 076 tis. Kč
    • •
  • MŠMT
Project

Improving therapy for childhood ambiguous lineage leukemia (NU23-07-00220)

to the results of drug response profiling and single cell analysis by classical and mass consortium and single cell laboratory techniques aiming at fine-tuning the treatment is less clear as the leukemic ...

Hematology

  • 2023 - 2026
    • •
  • 13 513 tis. Kč
    • •
  • 13 513 tis. Kč
    • •
  • MZ
Project

Quantification and localization of maternal mRNAs in early development of Xenopus (KJB500520601)

Cell determination during early development is a process that directly depends on protein and mRNA cell content and distribution. mRNA profiling is limited by small amounts of RNA in mammalian cells. On the contrar...

EB - Genetika a molekulární biologie

  • 2006 - 2007
    • •
  • 720 tis. Kč
    • •
  • 720 tis. Kč
    • •
  • AV ČR
  • 1 - 10 out of 7 111