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9 (0,188s) •

Project

Membrane signalosomes of mast cells and basophils - targets for innovative therapies (LD12073)

The aim of this project is: 1. To contribute to determining the composition of the FceRI membrane signalosomes important for antigen-induced degranulation in mast cells. 2. To contribute to determining the composition of membrane signalosomes importa...

EC - Imunologie

  • 2012 - 2014
    • •
  • 1 500 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • MŠMT
Project

Cyclooxygenases down-regulation and the influence on the gene expression (NR8760)

or retrovirus mediated shRNA expression, respectively. The gene expression profile...

EB - Genetika a molekulární biologie

  • 2006 - 2009
    • •
  • 6 423 tis. Kč
    • •
  • 6 370 tis. Kč
    • •
  • MZ
Project

Significance of asporin and other extracellular matrix proteins in invasive carcinomas of breast and prostate (NS9956)

1. Expression of asporin and other extracellular matrix related proteins (CTHRC1, POSTN, LRRC15, CSPG2) will be analysed after modulation of TGF beta and Wnt signaling pathways. 2. Importance of asporin in invasive growth will be studied after its kn...

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 3 805 tis. Kč
    • •
  • 3 791 tis. Kč
    • •
  • MZ
Project

Cellular Aging in haematological malignancy (NT14310)

, gene down-regulation by specific shRNAs and small inhibitory drugs will be used...

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 8 570 tis. Kč
    • •
  • 8 511 tis. Kč
    • •
  • MZ
Project

Role of S-phase kinase-associated protein 2 in biology of prostate cancer stem cells and tumor progression (NT13573)

1. Expression of Skp2 will be analyzed in various subpopulations of prostate cancer stem cells and after modulation of AR activity and EMT-inducing signaling pathways. 2. Importance of Skp2 in biology of cancer stem cells and prostate cancer progress...

FD - Onkologie a hematologie

  • 2012 - 2015
    • •
  • 8 938 tis. Kč
    • •
  • 8 938 tis. Kč
    • •
  • MZ
Project

L1 retrotransposon-based transgenic chicken models (GA523/07/1171)

L1 retrotransposons are major long interspersed nucleotide elements (LINEs) within the human genome. As autonomous retrotransposons, L1s were recently used for transgenesis in mouse and for transduction of RNA interference-inducing shRNAs. W...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 2007 - 2009
    • •
  • 4 247 tis. Kč
    • •
  • 4 247 tis. Kč
    • •
  • GA ČR
Project

HMGB proteins involvement in biology of telomeres and human embryonic stem cells (GAP305/12/2475)

the impact of deregulated expression of HMGB1 or other HMGBs (silencing by shRNA...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 9 740 tis. Kč
    • •
  • 9 740 tis. Kč
    • •
  • GA ČR
Project

Identification of novel antiviral targets in the nucleus of hepatitis B virus infected cells (GN24-11554O)

is to use shRNA-encoding lentivirus screening in cell-based cccDNA reporter assay...

Virology

  • 2024 - 2027
    • •
  • 5 273 tis. Kč
    • •
  • 5 273 tis. Kč
    • •
  • GA ČR
Project

Targeted Depletion of the TRP-VR1 in Murine Nociception Models for Treatment of Analgesics Resistant Pain (LTAB19024)

in vivo. This effect is achieved through targeted lentiviral shRNA interference...

Neurosciences (including psychophysiology)

  • 2019 - 2021
    • •
  • 1 200 tis. Kč
    • •
  • 1 200 tis. Kč
    • •
  • MŠMT
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