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9 (0,074s) •

Project

Dishevelled - identification of basic coordinates (GA15-21789S)

Dishevelled (Dvl) is the key component of the Wnt signaling cascades. The detailed information on the signal transduction via Dvl is however missing despite the intense recent research on this topic. This is mainly because the basic descrip...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 6 498 tis. Kč
    • •
  • 6 498 tis. Kč
    • •
  • GA ČR
Project

Understanding cell compartment and liquid phase restricted functions of Dishevelled (GA22-25365S)

The project will address how Dishevelled (DVL), the key signaling regulator in the Wnt pathway, achieves its multitude of functions. The basis of the project will be the focus on the biochemistry of the purified full length DVL3. We will add...

Cell biology

  • 2022 - 2024
    • •
  • 13 338 tis. Kč
    • •
  • 13 326 tis. Kč
    • •
  • GA ČR
Project

Posttranslational modification of Dishevelled (KJB501630801)

branches of Wnt signalling is a scaffolding protein Dishevelled (Dvl). In the present...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 1 290 tis. Kč
    • •
  • 1 290 tis. Kč
    • •
  • AV ČR
Project

Influence of Dishevelled posttranslational modifications on Wnt signaling pathways (GP13-31488P)

Wnt signaling pathways are the key morphogenetic pathways used both during embryonic development and in the adult to control cell proliferation, differentiation and motility. Deregulation of these processes can be causal for cancer growth and spreadi...

EB - Genetika a molekulární biologie

  • 2013 - 2015
    • •
  • 1 806 tis. Kč
    • •
  • 1 806 tis. Kč
    • •
  • GA ČR
Project

Dynamics of proteins interacting with Dishevelled and their importance for Wnt signalling (GA204/09/0498)

Mutations in the Wnt signalling pathway cause several human diseases including cancer. The aim of the project is to study in detail the proteins binding Dishevelled (Dvl) ? a key component of the Wnt signalling pathway. We plan to describe t...

CE - Biochemie

  • 2009 - 2013
    • •
  • 6 895 tis. Kč
    • •
  • 6 895 tis. Kč
    • •
  • GA ČR
Project

Understanding the order-disorder continuum in Dishevelled function and Wnt signaling (GA23-06913S)

The Dishevelled (DVL) protein provides a central hub for Wnt-signaling pathways. Up until now, experimental approaches to describe DVL functions have been reductionist, analyzing the DVL structured domains in isolation. Yet, two thirds of th...

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 13 215 tis. Kč
    • •
  • 13 215 tis. Kč
    • •
  • GA ČR
Project

Solving the WNT pathway mystery by the analysis of Dishevelled structure (GA18-17658S)

The proposal aims is to describe dynamics of DVL conformation and understand mechanisms that control it. We will take advantage of recent advances in structural proteomics/structural biology and unique reagents/unpublished information gathered in the...

Cell biology

  • 2018 - 2020
    • •
  • 7 122 tis. Kč
    • •
  • 6 823 tis. Kč
    • •
  • GA ČR
Project

The role of beta-arrestin in achieving Wnt-signaling specificity (GC204/09/J030)

beta-arrestin has been originally described as a component of Clathrin-mediated G protein-coupled receptor (GPCR) internalization. Recent studies demonstrated that beta-arrestin is required for Dishevelled (Dsh/Dvl) function in canonical and...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 3 888 tis. Kč
    • •
  • 3 888 tis. Kč
    • •
  • GA ČR
Project

Structural biology of the Wnt/PCP signaling pathway (LUAUS25170)

and Dishevelled (DVL). To achieve our goals, we will use an integrated approach...

Biochemistry and molecular biology

  • 2025 - 2028
    • •
  • 11 980 tis. Kč
    • •
  • 11 980 tis. Kč
    • •
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