Filters
Biodistribution and real-time monitoring of free or apoferritin-encapsulated charged cholinesterase reactivators (GA22-14568S)
Oxime cholinesterase reactivators are used for life endangering intoxications caused by organophosphate agents. However, clinically used (so called charged reactivators) or experimental uncharged reactivators have very limited penetration in...
Toxicology
- 2022 - 2024 •
- 11 763 tis. Kč •
- 11 208 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2022 - 31. 12. 2024
Uznané náklady
Podpora ze státního rozpočtu (95%)
Poskytovatel: Grantová agentura České republiky
*New systems of NPL detection in special-interest area - development of monitoring systém based on ensymsensors with cholinesterases (2A-1TP1/007)
*The project is focused on the design, development and testing of an enzyme sensor with cholinesterase suitable for rapid detection of nerve agents, namely organophosphates. The principle of detection will be based on inhibition of choli...
KA - Vojenství
- 2006 - 2008 •
- 20 176 tis. Kč •
- 10 925 tis. Kč •
- MPO
Řešení projektu: 7. 10. 2006 - 31. 12. 2008
Uznané náklady
Podpora ze státního rozpočtu (54%)
Poskytovatel: Ministerstvo průmyslu a obchodu
The research of modified cholinesterase reactivators for organophosphorus pesticide poisoning treatment (LH13009)
The aim of the proposed project consists in the synthesis, in vitro and in vivo evaluation of the modified cholinesterase reactivators. The modified reactivators will differ from currently available compounds in their structure, where their ...
FR - Farmakologie a lékárnická chemie
- 2013 - 2015 •
- 1 763 tis. Kč •
- 1 763 tis. Kč •
- MŠMT
Řešení projektu: 15. 3. 2013 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
*Construction of simple dipstickfor organophosphates assay (FR-TI1/541)
*The submitted project is focused on an actual problem: detection of compounds with antiocholinergic properties using a simple dipstick based on recognition capability of cholinesterases. Organophosphates and carbamates will be assayed durin...
CB - Analytická chemie, separace
- 2009 - 2011 •
- 10 576 tis. Kč •
- 6 599 tis. Kč •
- MPO
Řešení projektu: 1. 3. 2009 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (62%)
Poskytovatel: Ministerstvo průmyslu a obchodu
Technology for new tube colorimetric biosensor of cholinesterase inhibitors in the air and in liquid samples (TA04011060)
The aim of the project is to gain knowledge of new methods and technologies that have subsequently enable to design, develop and manufacture a new tube colorimetric biosensor toxic chemicals performers on the human (mammalian) body as a strong inhibi...
CB - Analytická chemie, separace
- 2014 - 2016 •
- 5 368 tis. Kč •
- 3 488 tis. Kč •
- TA ČR
Řešení projektu: 1. 7. 2014 - 30. 6. 2016
Uznané náklady
Podpora ze státního rozpočtu (65%)
Poskytovatel: Technologická agentura ČR
Novel prophylactic antidotes of nerve agent poisonings based on scavengers (OVUOFVZ200902)
(atropine, benactyzine) and cholinesterase reactivators (pralidoxime, obidoxime, HI-6). Favorable solution is using of specific enzymes (mostly cholinesterases) as scavengers their toxic effect in the organism. We would like to fin...
FP - Ostatní lékařské obory
- 2009 - 2012 •
- 1 792 tis. Kč •
- 864 tis. Kč •
- MO
Řešení projektu: 1. 7. 2009 - 31. 12. 2012
Uznané náklady
Podpora ze státního rozpočtu (48%)
Poskytovatel: Ministerstvo obrany
Encapsulation of bisquaternary oxime reactivators into solid lipid nanoparticles for enhanced reactivation of cholinesterases in CNS (GA25-15339S)
Quaternary oxime reactivators of cholinesterases are used for life endangering intoxications by organophosphates. They are effective in the peripheral tissues, but their penetrability and therapeutic effectiveness in the central nervous syst...
Neurosciences (including psychophysiology)
- 2025 - 2027 •
- 13 027 tis. Kč •
- 13 027 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2025 - 31. 12. 2027
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Modified oxime nucleophiles for reactivation of phosphylated cholinesterases (LUAKR25007)
Organophosphorus compounds are used as insecticides or misused as chemical warfare agents and they can cause life endangering intoxications. Reactivators of acetylcholinesterase so called oximes are causal treatment of such intoxications. Oximes are ...
Medicinal chemistry
- 2025 - 2028 •
- 5 000 tis. Kč •
- 5 000 tis. Kč •
- MŠMT
Řešení projektu: 1. 10. 2025 - 30. 9. 2028
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
READER_CH - highly sensitive detector intended for detection of CWAs based on cholinesterase inhibitors (OFVVU20130007)
The object of this development project is design, construction and testing of a prototype of personal detector of chemical warfare agents that inhibit cholinesterase (organophosphorus CWA of G and V type). For the detection of interest CWA d...
KA - Vojenství
- 2013 - 2016 •
- 12 927 tis. Kč •
- 12 927 tis. Kč •
- MO
Řešení projektu: 21. 10. 2013 - 30. 9. 2016
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo obrany
Effect of cholinesterase inhibitors on monoaminergic system and energy metabolism (GJ17-07585Y)
Cholinesterase (ChE) inhibitors play an essential role in the treatment of Alzheimer’s disease (AD), they effect positively cognitive, functional and behavior symptoms of AD. Up to date, donepezil, rivastigmine and galantamine represent the ...
FH - Neurologie, neurochirurgie, neurovědy
- 2017 - 2022 •
- 4 776 tis. Kč •
- 4 776 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2017 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
- 1 - 10 out of 27