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153 (0,118s) •

Project

Targeting and activity of RTX toxins of Gram-negative pathogens (GA22-01558S)

Both the adenylate cyclase toxin (CyaA) and the α-hemolysin (HlyA) are RTX toxins playing a key role in virulence of Bordetella pertussis and Escherichia coli permeabilize cellular membrane by forming of cation-selective pores. Both...

Microbiology

  • 2022 - 2024
    • •
  • 9 762 tis. Kč
    • •
  • 9 762 tis. Kč
    • •
  • GA ČR
Project

Preparation of the collection of biologically significant toxins with the support of European biological European biodefence laboratory network (VH20172020012)

The aim of this public contract is the establishment of the wider collection of standards and analytic techniques for biological toxins based especially on the preparation of recombinational toxins and mass spektrometry.......

EB - Genetika a molekulární biologie

  • 2017 - 2020
    • •
  • 19 224 tis. Kč
    • •
  • 19 074 tis. Kč
    • •
  • MV
Project

Research to improvement of biological agents and toxins (JA204032004)

with prohibition of biological and toxins weapons and trade law changing) with fast methods of detection and identification of biological agents and toxins. The project links up task) of highly hazardous biological agents and t...

CE - Biochemie

  • 2004 - 2007
    • •
  • 8 000 tis. Kč
    • •
  • 8 000 tis. Kč
    • •
  • SÚJB
Project

Ultra-sensitive detection of toxins based on immuno-PCR methods (VI20192022150)

The project is focused on developing toxin detection metohod using innovative approach of emloing innovative connection of techniques of immunochemistry and molecular biology. The aim is to develop sensitive toxin detection methodol...

Other biological topics

  • 2019 - 2022
    • •
  • 4 031 tis. Kč
    • •
  • 4 031 tis. Kč
    • •
  • MV
Project

The application of microbial toxins for supression of mites in stored products (OC08065)

by allergen and chemical contaminants increasing the food safety. The microbial toxins) the analysis of proteolytic conditions for activation/inactivation of Bt toxins in mite gut; (iii) screening the toxic activity of microorganis...

GF - Choroby, škůdci, plevely a ochrana rostlin

  • 2008 - 2009
    • •
  • 1 000 tis. Kč
    • •
  • 1 000 tis. Kč
    • •
  • MŠMT
Project

Investigation of the methods for toxin analysis under conditions of mobile and stationary laboratories. (OSVTUO2007005)

Practical experimental checking of the possibilities for analysis and quantification of the selected toxins by the field analytical system PPCHL AL-2 and development of the standard operating procedures.......

KA - Vojenství

  • 2007 - 2009
    • •
  • 6 146 tis. Kč
    • •
  • 6 146 tis. Kč
    • •
  • MO
Project

Nature and role(s) of the posttranslational modification(s) required for activities of an RTX toxin the adenylate cyclase toxin of bordetella pertussis (GA310/95/1048)

EE - Mikrobiologie, virologie

  • 1995 - 1997
    • •
  • 1 030 tis. Kč
    • •
  • 1 030 tis. Kč
    • •
  • GA ČR
Project

Toxins as potentially misusage chemical and biological agents. (MO66021299116)

The main of this project is to obtain schedule about toxins with military importance and establish their database....

FP - Ostatní lékařské obory

  • 1999 - 2000
    • •
  • 275 tis. Kč
    • •
  • 275 tis. Kč
    • •
  • MO
Project

Design of default and accredited identification methods (direct and indirect) of highstake biological agens and toxins (JB8/03)

of biological agents and toxins. SÚJB cannot execute this activity only by its own facility. The methods of biological agents and toxins identification will be introduced according of biological agents and toxins mass spec...

EE - Mikrobiologie, virologie

  • 2003 - 2003
    • •
  • 1 800 tis. Kč
    • •
  • 1 800 tis. Kč
    • •
  • SÚJB
Project

Investigation of the mechanism of membrane translocation of the adenylate cyclase toxin (IAA5020907)

The adenylate cyclase toxin (ACT) paralyses a variety of cells by uncontrolled synthesis of cAMP. Penetration of ACT into cells is a rather iniwue example by fluorescence spectroscopy and immunodetection, using our set of appropriately tagge...

CE - Biochemie

  • 1999 - 2003
    • •
  • 7 321 tis. Kč
    • •
  • 4 975 tis. Kč
    • •
  • AV ČR
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