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5 453 (0,082s) •

Project

Analysis of intracellular IL-1RA isoforms in patients with juvenile idiopathic arthritis and their relation to clinical features of the disease (NR7922)

and IL-1RN*1/1, IL-1RN*1/2 a IL-1RN*2/2 genotypes in JIA patients and controls participates in the maintenance of IL-1/IL-1RA balance, whether their activity is limited...

FG - Pediatrie

  • 2004 - 2006
    • •
  • 5 022 tis. Kč
    • •
  • 4 826 tis. Kč
    • •
  • MZ
Project

IL-2 complexed with muteins of JES6-1 mAb having different affinity to IL-2 finding variant with most selective stimulation of Treg cells in vivo (GA18-12973S)

Complexes of IL-2 and anti-IL-2 mAb JES6-1 potently expand CD25+ cells, i.e receptor. JES6-1 mAb sterically blocks the interaction of IL-2 with CD122 and CD132 to “triggered exchange” mechanism, CD25 displ...

Immunology

  • 2018 - 2022
    • •
  • 4 804 tis. Kč
    • •
  • 4 762 tis. Kč
    • •
  • GA ČR
Project

Predictive immunological markers in patients with hepatitis C viral infection (NT14072)

with chronic hepatitis C (HC), genotype 1b in Prague and Hradec Králove: 1) Expression in laboratory in Prague using FlowCytomix methodology: IL-1b, IL-2, IL-4, IL-5, IL-6, IL-10, IL...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2013 - 2015
    • •
  • 7 567 tis. Kč
    • •
  • 7 567 tis. Kč
    • •
  • MZ
Project

Cytokinin and acute phase proteins in laboratory diagnosis and prognosis of human ovarian cancer. (IZ2258)

9F - 9

  • 1994 - 1996
    • •
  • 212 tis. Kč
    • •
  • 424 tis. Kč
    • •
  • MZ
Project

Immunogenetics of lung inflammation VNTR polymorphims of IL-1RA (IL-1 receptor antagonist) gene and pulmonary fibrosis (idiopathic, secondary) (GA310/99/1676)

Interleukin-1 (IL-1), which is blocked by its natural antagonist (IL-1RA*), is implicated in the pathogenesis of pulmonary fibrosis (PF). The aim of the project is to investigate if allele 2 of IL-1RA gene...

EC - Imunologie

  • 1999 - 2001
    • •
  • 597 tis. Kč
    • •
  • 597 tis. Kč
    • •
  • GA ČR
Project

HLA polymorphism and polymorphism of cytokine genes in pemphigus vulgaris (MEB080892)

Research aim of the project is to investigate gene polymorphism (single nucleotide polymorphisms), particularly of TH2 cytokines (IL-4, IL-5, IL-6) and proinflammatory cytokines (IL-1, TNF, IFN-γ) in ...

EE - Mikrobiologie, virologie

  • 2008 - 2009
    • •
  • 24 tis. Kč
    • •
  • 24 tis. Kč
    • •
  • MŠMT
Project

Monocyte subpopulations in kidney transplantation and regulatory mechanisms of human macrophage differentiation (NS10524)

production. Cytokines from IL-1 family (IL-1beta, IL-18, IL-33) and TNF alfa and furthermore, cytokines associated withTh1/Th2/Th17 polarization (IFN gama, IL-4, IL-13, IL-23, <...

EC - Imunologie

  • 2009 - 2011
    • •
  • 4 206 tis. Kč
    • •
  • 4 206 tis. Kč
    • •
  • MZ
Project

Development of cytokine regulation of the immune response in bacterial infections in the pig (GA524/99/0518)

-inflammatory cytokines (IL-1alfa, IL 1-ß, IL-4, IL-6, IL-8, IL-10, IL-18, IFN-gama, TNF cytokinesor their receptors will be used to simulate: 1) syndrome of intraamniot...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1999 - 2001
    • •
  • 2 150 tis. Kč
    • •
  • 1 780 tis. Kč
    • •
  • GA ČR
Project

Complexes of IL-2 and anti-IL-2 mAb with selective stimulatory activity for CD25+ T cells in cancer immunotherapy changing the paradigm (GA22-20548S)

Complexes of IL-2 and anti-IL-2 mAbs possess extremely high biological activity in vivo. Moreover, such IL-2 complexes have selective stimulatory activity for different IL-2 responsive cells depending on the clone ...

Oncology

  • 2022 - 2024
    • •
  • 8 330 tis. Kč
    • •
  • 8 330 tis. Kč
    • •
  • GA ČR
Project

Ontogeny of pig enterleukin 18 production and its role in bacterial infections (GA524/02/1217)

. It is suggested to study: 1. IL-18 in the pig in prenatal and early postnatal period (IL-18 ofcaspase-1 and FasL in bacterial infections.Better understanding of the role of IL-18 of gestation). 2. IL...

EC - Imunologie

  • 2002 - 2004
    • •
  • 3 391 tis. Kč
    • •
  • 2 267 tis. Kč
    • •
  • GA ČR
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