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18 (0,105s) •

Project

Modulation of uncoupling protein UcP2 and mitochondrial bioenergetics in cardiomyocytes by natural substances (GA303/08/0658)

Uncoupling protein 2 (UcP2) is involved in modulation of superoxide production by mild uncoupling of mitochondrial respiration. However, increased UcP2 seems to be associated with heart failure, but low UcP2 is unfavorable ...

CE - Biochemie

  • 2008 - 2010
    • •
  • 2 704 tis. Kč
    • •
  • 2 704 tis. Kč
    • •
  • GA ČR
Project

Molecular properties of mitochondrial uncoupling proteins (1P05ME794)

elucidation of interaction between UCP2 and hydrooxides of fatty acids and other relevant products of lipoporoxidation, ph dependence of ion transport mediated by UCP2......

ED - Fyziologie

  • 2005 - 2008
    • •
  • 3 090 tis. Kč
    • •
  • 1 545 tis. Kč
    • •
  • MŠMT
Project

Variations of mRNA for novel mitochondrial uncoupling protein UCP2 upon stimulation by pyrogenic cytokines (GP301/01/P084)

Studies are proposed which should elucidate participation of the novel mitochondrial uncoupling protein UCP2 in fever. It was previously observed that UCP2 mRNA increases in liver as well as in hepatocytes (also in white fat and ske...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 1 522 tis. Kč
    • •
  • 661 tis. Kč
    • •
  • GA ČR
Project

Elucidation of role of mitochondrial factor CIDEa in normal physiology, antioxidant defense, and in type-2 diabetes and obesity (GA301/05/0221)

, CIDE3) may interact and inhibit also the ubiquitously expressed UCP2 in vivo and that factors disrupting CIDEa interaction with UCP2, including reactive oxygen species (ROS) and their products, are those which initiate UCP2

CE - Biochemie

  • 2005 - 2007
    • •
  • 2 982 tis. Kč
    • •
  • 2 982 tis. Kč
    • •
  • GA ČR
Project

Role of mitochondrial lipoperoxidation in concert with uncoupling in feedback downregulation of oxidative stress (GA303/07/0105)

phospolipases A2 in concert with uncoupling due to UCP2 in feedback downregulation of oxidative stress. We will also use UCP2 KO mice. We will estimate a threshold for released free hydroperoxy-fatty acids, above which UCP2

CE - Biochemie

  • 2007 - 2011
    • •
  • 4 900 tis. Kč
    • •
  • 4 900 tis. Kč
    • •
  • GA ČR
Project

Interaction of superoxide and reactive oxigen species with mitochondral uncoupling proteins (GA204/04/0495)

) or reactive nitrogen species (RNS) and mitochondrial uncoupling proteins UCP2 (or UCP3 UCP2 function leads to a decrease in mitochondrial ROS production is activated or RNS interact with UCP2 indirectly, via their reactio...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 2 469 tis. Kč
    • •
  • 2 469 tis. Kč
    • •
  • GA ČR
Project

Significance of mitochondrial uncoupling in pancreatic beta cells for development of type-2 diabetes. (NR7917)

We'll study mitochondrial uncoupling of pancreatic beta-cells due to enhanced expression/function of uncoupling protein UCP2 &other genes, blocking glukose-sensitive by upregulators of UCP2 expression and potential blocking drugs wi...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2009
    • •
  • 12 765 tis. Kč
    • •
  • 8 453 tis. Kč
    • •
  • MZ
Project

Mitochondrial "uncoupling proteins" in liver and skeletal muscle during perinatal development (NE6430)

the liver UCP2 expression in premature human newborns, in the relationship to pre- and postnatal infection. (2) To learn whether UCP2 expression in myelocytes is affected,for identification of the cell types with UCP2 and ...

EB - Genetika a molekulární biologie

  • 2001 - 2005
    • •
  • 8 834 tis. Kč
    • •
  • 4 920 tis. Kč
    • •
  • MZ
Project

Role of mitochondrial reactive oxygen species in regulation of pancreatic beta cell function (GPP304/10/P204)

to examine details of UCP2 role in regulation of GSIS and ROS homeostasis in pancreatic b-cells. Lentiviral expression system with cassette for miRNA targeting UCP2 will beused to regulate UCP2 levels in primary cultures. ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2010 - 2013
    • •
  • 1 491 tis. Kč
    • •
  • 1 491 tis. Kč
    • •
  • GA ČR
Project

Fatty acid cycling by phosphate carrier and uncoupling protein 2. (ME 389)

nucleotide binding to UCP2 using surface plasmon resonance spectroscopy and influence...

EB - Genetika a molekulární biologie

  • 2000 - 2003
    • •
  • 1 780 tis. Kč
    • •
  • 1 100 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 18