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4 969 (0,09s) •

Project

Molecular mechanisms of functional selectivity of atypical agonists at muscarinic receptors (GA305/09/0681)

receptor conformational changes and oligomerization, and molecular modeling to verifyEach of the five known subtypes of muscarinic acetylcholine receptors is involved in specific physiological functions. Drugs targeted at ...

ED - Fyziologie

  • 2009 - 2013
    • •
  • 6 959 tis. Kč
    • •
  • 6 959 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of allosteric modulation of muscarinic acetylcholine receptors by neurosteroids and cholesterol (GA19-05318S)

Given the broad range of functions that muscarinic receptors serve with muscarinic receptor subtypes constitute the basis for functional selectivity of xanomeline. The possibility to achieve pharmacological selectivity based on ...

Physiology (including cytology)

  • 2019 - 2021
    • •
  • 7 213 tis. Kč
    • •
  • 7 015 tis. Kč
    • •
  • GA ČR
Project

The role of cyroskeleton in degradation of glucocorticoid receptor GR) and aromatic hydrocarbon receptor (AhR) (1P05ME767)

clarification of molecular mechanisms involved in the transcription activity and degradation of GR as a result of disintegradion of cytosceleton......

CE - Biochemie

  • 2005 - 2006
    • •
  • 650 tis. Kč
    • •
  • 168 tis. Kč
    • •
  • MŠMT
Project

Delineation of molecular mechanisms enhancing death-receptor mediated apoptosis in tumor cells (GA301/03/0545)

Defects in the molecular mechanisms controling either cell division or apoptosis can lead to malignancies. The biochemical machinery of cell death comprises caspases that can be activated by the engagement of surface death receptors...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 792 tis. Kč
    • •
  • 792 tis. Kč
    • •
  • GA ČR
Project

The role of nuclear hormone receptors in regulation of differentiation of cancer cells. (NM6253)

A study focused on identification of nuclear hormone receptors and their regulatory pathways may be important for regulation of differentiation of cancer cells.......

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 3 200 tis. Kč
    • •
  • 3 200 tis. Kč
    • •
  • MZ
Project

Laboratory of Molecular Physiology and Immunology (VS97099)

Signal molecules and their receptors regulate metabolic and immune responses of target cells. The proposed project establishes experimental basis for the research of molecular mechanisms of the action of signaling molecules and repr...

ED - Fyziologie

  • 1997 - 2000
    • •
  • 27 837 tis. Kč
    • •
  • 22 995 tis. Kč
    • •
  • MŠMT
Project

Role of hyaluronan of different molecular weight in the course of inflammation (GA305/08/1704)

HA receptors. During inflammation, high molecular weight HA is degraded to HA fragments that have distinct affinity to particular HA receptors. We hypothesize the HA of particular molecular weight carries a specif...

FR - Farmakologie a lékárnická chemie

  • 2008 - 2010
    • •
  • 2 859 tis. Kč
    • •
  • 2 859 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanism of GABA B receptor regulation by KCTD proteins (GA14-28334S)

the molecular mechanism of GABA B receptor modulation by KCTDs using biochemicalGABA B receptor is the metabotropic receptor for the main inhibitory identified as auxiliary subunits of the GABA B receptors

FH - Neurologie, neurochirurgie, neurovědy

  • 2014 - 2018
    • •
  • 4 425 tis. Kč
    • •
  • 4 425 tis. Kč
    • •
  • GA ČR
Project

Interleukins of the IL-10 family specificity and targeted modulation of interactions with receptors (GA16-20507S)

of their receptors, and modulate these interactions by directed in vitro evolution of a novel of their interaction with receptors, and ways how they preserve specificity in systems with shared receptors. Inhibitors disrupt...

EB - Genetika a molekulární biologie

  • 2016 - 2018
    • •
  • 7 404 tis. Kč
    • •
  • 7 290 tis. Kč
    • •
  • GA ČR
Project

Study of glutamate receptors conformational changes using novel fluorescent techniques (GA303/08/1591)

The activation mechanism of the metabotropic glutamate receptors and GABAb receptors is studied extensively in our laboratory. We aim to describe molecular events that result from competitive ligand binding or actions of ne...

FR - Farmakologie a lékárnická chemie

  • 2008 - 2012
    • •
  • 6 985 tis. Kč
    • •
  • 6 985 tis. Kč
    • •
  • GA ČR
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