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23 (0,064s) •

Project

Regulation of intravascular triglyceride catabolism by acute hyperinsulinemia and hyperglycemia. (NB6368)

Effect of acute hyperinsulinemia and/or hyperglycemia on total lipoprotein lipase activity in the body determined in vivo using intravenous fat tolerance test will be analyzed.......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2000 - 2002
    • •
  • 2 216 tis. Kč
    • •
  • 2 187 tis. Kč
    • •
  • MZ
Project

Validation of diagnostic approach in children and adolescents with randomly found hyperglycemia. (NB7420)

In about 100 children and adolescents, the cause of randomly found hyperglycemia will be estimated using metabolic investigation, estimation of autoantibodies and molecular genetic analysis. A diagnostic flowchart for clinical routine will b...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
    • •
  • 2 341 tis. Kč
    • •
  • 2 322 tis. Kč
    • •
  • MZ
Project

The effect of glucose variability on the pathogenetic mechanisms of development of vascular changes in type 1 diabetes (NV15-26705A)

by hyperglycemia. It activates oxidative stress and advanced protein glycation, the main pathogenic factors in the development of chronic complications. Hyperglycemia has two components: chronic sustained hyperglycemia and...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2015 - 2019
    • •
  • 4 275 tis. Kč
    • •
  • 4 275 tis. Kč
    • •
  • MZ
Project

Studying molecular biologic responses to intensive insulin therapy during lung resections (NS9681)

The aim is to confirm or deny the hypothesis that insulin affects diffusion capacity of lungs, probably due to an increased fluid capacity of alveolar capillaries. Simultaneously the microarray technology will be used to map the impact of insulin on ...

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 3 118 tis. Kč
    • •
  • 3 052 tis. Kč
    • •
  • MZ
Project

The role of CNS in the pathophysiology of insulin resistance (NR8991)

The aim of the study is to evaluate the effect of acute hyperinsulinemia on MR Spectroscopy of the brain tissue, neurosteriod and adipokine metabolism in diabetic, insulin-resistant and healthy subjects. The aim of the study is to evaluate the effect...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006 - 2008
    • •
  • 9 941 tis. Kč
    • •
  • 9 003 tis. Kč
    • •
  • MZ
Project

The effect of simultaneous pancreas and kidney transplantation with long term normoglycemia on small fibre diabetic neuropathy (NR7929)

Diabetic neuropathy is caused by long-term hyperglycemia and affects nerve fibres of various types. Small fibre neuropathy may be assessed by epidermal nerve fibre counts in skin biopsies. The aim of the project is the longitudinal follow-up...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2007
    • •
  • 2 229 tis. Kč
    • •
  • 1 944 tis. Kč
    • •
  • MZ
Project

Dynamic parameters of glucose control in relation to biomarkers in serum and intraocular fluid in diabetic patients with ocular complications (NU22-01-00077)

complications beyond the sustained hyperglycemia. Transient glucose spikes can induce to a more severe form, additionally and beyond the sustained chronic hyperglycemia......

Endocrinology and metabolism (including diabetes, hormones)

  • 2022 - 2025
    • •
  • 14 529 tis. Kč
    • •
  • 14 529 tis. Kč
    • •
  • MZ
Project

Relationship between genetic variability of antioxidant system and late complications of diabetes mellitus (GP303/02/D127)

of hyperglycemia-driven enhanced formation of reactive oxygen species in diabetes. Theaim...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2002 - 2004
    • •
  • 545 tis. Kč
    • •
  • 545 tis. Kč
    • •
  • GA ČR
Project

Signal transduction of angiotensin II in diabetes mellitus and its modulation by glucose, insulin a insulin resistance (NR8221)

and hyperglycemia (Akt kinase, MAP kinases)....

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 5 049 tis. Kč
    • •
  • 4 585 tis. Kč
    • •
  • MZ
Project

The effect of pancreas transplantation on epidermal innervation and growth factor expression in type 1 diabetes mellitus (NT13014)

The pathogenesis of diabetic peripheral neuropathy (DPN) involves hyperglycemia-linked mechanisms which may include changes in the expression of growth factors. In the course of the project epidermal nerve fibre densities and expression of v...

FH - Neurologie, neurochirurgie, neurovědy

  • 2012 - 2015
    • •
  • 2 790 tis. Kč
    • •
  • 2 790 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 23