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1 694 (0,095s) •

Project

Mitochondrial and nuclear DNA cross-talk and its impact on metabolic phenotype and innate immunity (GA19-10354S)

circular DNA (mtDNA). Human mtDNA exerts considerable sequence variability dividing the population into different mtDNA subpopulations known as haplogroups. Recently, many studies suggested that mtDNA m...

Endocrinology and metabolism (including diabetes, hormones)

  • 2019 - 2022
    • •
  • 6 634 tis. Kč
    • •
  • 6 580 tis. Kč
    • •
  • GA ČR
Project

Genetic structure of sika deer populations in the Czech Republic (GA524/09/1569)

1. Analysis of the genetic structure of populations of sika deer (mtDNA, microsatellites) 2. Determining the origin of introduced individuals 3. The determination of degree of hybridization populations of sika deer and red deer 4. Specific s...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 2009 - 2011
    • •
  • 3 106 tis. Kč
    • •
  • 3 106 tis. Kč
    • •
  • GA ČR
Project

Molecular aspects and biochemical and clinical consequences of maternally inherited mitochondrial disorders (NR8065)

Maternally inherited mitochondrial disorders due to mtDNA mutations represent the hypothesis that beside the level of heteroplasmy of pathogenic mtDNA mutations also the mtDNA haplotype, absolute amount of mtDNA, a...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 4 910 tis. Kč
    • •
  • 4 909 tis. Kč
    • •
  • MZ
Project

Molecular markers applied for management of lines, strains and species of commercially important fishes in the Czech Republic (IBS5045011)

The detailed knowledge of genetic struktures of lines, strains and species of commercially important fishes underlies the regular fish breeding and improvement and the management of wild fish populations. Application of described markers or developin...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 2000 - 2004
    • •
  • 5 795 tis. Kč
    • •
  • 3 000 tis. Kč
    • •
  • AV ČR
Project

The role of mitochondrial respiration in tumour initiation and growth A mechanistic study (GC17-01192J)

Cancer cells are so dependent on mitochondrial mtDNA for their growth, that in case of damage to their mtDNA, they acquire mitochondrial genome from host cells. Horizontal transfer of mtDNA is required for tumour formation,...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 7 860 tis. Kč
    • •
  • 7 860 tis. Kč
    • •
  • GA ČR
Project

Molecular and other genetic markers applied in conservation of populations of endangered, rare and vanishing fish species in CR (IBS5045111)

or developing of new ones (RFLP, mtDNA, ploidy identification) for identification of CIU...

GL - Rybářství

  • 2001 - 2005
    • •
  • 8 307 tis. Kč
    • •
  • 5 045 tis. Kč
    • •
  • AV ČR
Project

Mitochondrial disorders with instability of mitochondrial DNA (NV17-30965A)

and mortality. OXPHOS biogenesis is under dual genetic control, mitochondrial DNA (mtDNA) and nuclear genome. Subgroup of MD is characterized by mtDNA instability. MtDNA deletions may be caused by mutations in nuclear gene...

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 13 003 tis. Kč
    • •
  • 12 960 tis. Kč
    • •
  • MZ
Project

Genetic analysis of the role of mitochondria in the pathogenesis of metabolic syndrome studied in new rat conplastic strains (GA301/08/0166)

Recently, the potential role of mitochondrial DNA (mtDNA) variants in common and the metabolic syndrome. Preliminary analysis of mtDNA sequence from SHR and Brown Norway (BN (SHRxBN)F1 females with identical nuclear genomes but with...

EB - Genetika a molekulární biologie

  • 2008 - 2011
    • •
  • 6 896 tis. Kč
    • •
  • 6 896 tis. Kč
    • •
  • GA ČR
Project

Intraspecific variability of populations of two cryptic bat species of genus Pipistrellus in Central Europe (GA206/06/0954)

the CzechRepublic. Achieved results suggest intraspecific variability of genetic characters, this variability has not been studied in the cryptic species of the genus Pipistrellus and behavioural adaptations. Based on intraspecific...

EG - Zoologie

  • 2006 - 2008
    • •
  • 4 251 tis. Kč
    • •
  • 4 251 tis. Kč
    • •
  • GA ČR
Project

Properties of horizontal mitochondrial transfer in cancer (GJ18-24753Y)

in the form of mitochondrial DNA (mtDNA). Cell type mtDNA heteroplasmy was reported before cells. Cellular mtDNA heterogeneity and transport are potentially connected in both for therapy. Our mouse strains with specific

Cell biology

  • 2018 - 2022
    • •
  • 5 898 tis. Kč
    • •
  • 5 898 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 1 694