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2 071 (0,092s) •

Project

Vital role of plasma membrane in cell interaction with exogenous proteins interaction of yeast plasma membrane with zymocines (GA204/00/0629)

, physiology or differentiation. Plasma membrane receptors are vital for this process membrane receptors for killer toxin and the mechanism of their interaction with the toxin(s), in particular: (1) specificity of ...

EE - Mikrobiologie, virologie

  • 2000 - 2002
    • •
  • 3 101 tis. Kč
    • •
  • 1 996 tis. Kč
    • •
  • GA ČR
Project

Biochemical studies of membrane rafts and immunoreceptors based on cell membrane-disintegrating copolymers (GA19-04047S)

Biochemical studies on cell membrane microdomains (especially membrane rafts) and membrane receptor complexes have been based on membrane disintegration by detergents, yielding detergent resistant memb...

Polymer science

  • 2019 - 2023
    • •
  • 7 933 tis. Kč
    • •
  • 7 648 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of allosteric modulation of muscarinic acetylcholine receptors by neurosteroids and cholesterol (GA19-05318S)

of membrane cholesterol level, receptor mutagenesis and analysis of interactions betweenGiven the broad range of functions that muscarinic receptors serve disorders. We found recently that differential interactions of ...

Physiology (including cytology)

  • 2019 - 2021
    • •
  • 7 213 tis. Kč
    • •
  • 7 015 tis. Kč
    • •
  • GA ČR
Project

Center of molecular and cellular immunology (LN00A026)

research of lymphocyte antigen-specific receptors, receptors of certaincytokines and hormonesand Fc-receptors. This research will be based on the hypothesis on a key role of supramolecular (domain) organization of plasma c...

EC - Imunologie

  • 2000 - 2004
    • •
  • 115 858 tis. Kč
    • •
  • 76 500 tis. Kč
    • •
  • MŠMT
Project

Glutamate receptor modulators synthesis and activity (GA203/01/0084)

Glutamate receptors in neuronal membranes affect many life functions in organisms. One type of glutamate receptors is connected with ion selective cationic channels and their activity depends on several ligands (modulators)...

CC - Organická chemie

  • 2001 - 2003
    • •
  • 3 951 tis. Kč
    • •
  • 1 512 tis. Kč
    • •
  • GA ČR
Project

The effect of cell membrane fluidity on the functional properties of NMDA receptors (GPP303/11/P391)

N-methyl-D-aspartate (NMDA) receptor is a ionotropic glutamate receptor, whose of cholesterol contents in plasma membrane of neurons has neuroprotective effect against NMDA receptor mediated excitotoxicity. Therefo...

ED - Fyziologie

  • 2011 - 2015
    • •
  • 2 195 tis. Kč
    • •
  • 2 195 tis. Kč
    • •
  • GA ČR
Project

The role of hydrophobic plasma membrane interior in DOR regulation of trimeric G protein activity (GAP207/12/0919)

The present understanding of the role of membrane organization in functional coupling between δ-opioid receptor (DOR) and the cognate G proteins is unclear. G protein activation is impaired by cholesterol depletion but

CE - Biochemie

  • 2012 - 2016
    • •
  • 9 965 tis. Kč
    • •
  • 9 965 tis. Kč
    • •
  • GA ČR
Project

Delta-opioid receptor targeting to membrane domains the role of palmitoylation (IAA500110606)

Palmitoylation is one of the most frequent posttranslational modifications, which has an important regulatory function in many G protein-coupled receptors, and it may presumably condition preferential partition of some receptors int...

CE - Biochemie

  • 2006 - 2010
    • •
  • 3 285 tis. Kč
    • •
  • 3 285 tis. Kč
    • •
  • AV ČR
Project

Mechanisms of membrane interaction and cytotoxic activity of adenylate cyclase (IAA5020406)

membrane. Its understanding is, hence, of general relevance for deciphering the principles of membrane interactions of proteins. We will tie-up on identification mechanisms underlying membrane insertion and translocation o...

CE - Biochemie

  • 2004 - 2008
    • •
  • 6 250 tis. Kč
    • •
  • 5 910 tis. Kč
    • •
  • AV ČR
Project

Role of membrane domains of NR1 and NR2 subunits in the assembly and trafficking of the NMDA receptor to the cell surface (GAP303/11/0075)

N-methyl-D-aspartate (NMDA) receptors mediate fast excitatory synaptic transmission in the mammalian central nervous system. Activation of NMDA receptors can, we will identify how inter-membrane domain interactions contribu...

FH - Neurologie, neurochirurgie, neurovědy

  • 2011 - 2013
    • •
  • 4 160 tis. Kč
    • •
  • 4 160 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 2 071