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2 163 (0,103s) •

Project

Studies on DNA damage and apoptosis by genotoxic stress (ME 534)

Genotoxic treatment induces in plants DNA damage and various defence mechanisms to repair or eliminate damaged cells. By expression profiling of selected genes and detection of DNA integrity by Comet Assay we want to elucid...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 2 639 tis. Kč
    • •
  • 633 tis. Kč
    • •
  • MŠMT
Project

Induced DNA damage, mutagenicity, homologous recombination and apoptosis as endpoints for monitoring effects of pollutants in tobacco and potato (GA521/05/0500)

of these agents, we will use: 1) the Comet assay for detecting DNA damage, 2) the GUS assay for detecting homologous recombination, 3) somatic mutation assay, 4) the TUNEL and Diffusion assay for detectin...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 2 536 tis. Kč
    • •
  • 2 536 tis. Kč
    • •
  • GA ČR
Project

Chemical modification and electrochemical analysis of nucleic acids as a new tool in molecular oncology (GA17-08971S)

to develop electrochemical assays for detection of DNA and RNA sequences, as well as for analysis of DNA methylation, an epigenetic modification regulating gene expression. Namely, we want to determine presence of oncovira...

CG - Elektrochemie

  • 2017 - 2019
    • •
  • 6 782 tis. Kč
    • •
  • 6 356 tis. Kč
    • •
  • GA ČR
Project

Monitoring DNA damage in model plants and agronomic crops exposed to environmental mutagens and agricultural chemicals (GA521/99/0532)

the single cell gel electrophoresis assay for detecting DNA damage in leavesWe propose to use a new plant based molecular genetic assay (Comet assay, single cell gel electrophoresis) to evaluate the genotoxicity o...

EB - Genetika a molekulární biologie

  • 1999 - 2001
    • •
  • 2 521 tis. Kč
    • •
  • 1 654 tis. Kč
    • •
  • GA ČR
Project

*Development of assays for thrombosis and atherosclerosis risk mutation detection (FR-TI1/507)

is the completation of the assays comprising primers, modified probes and control DNA. Finished*Project deals with the research and developments in the field of DNA mutation is based on the use of real-time PCR in combinat...

EB - Genetika a molekulární biologie

  • 2009 - 2012
    • •
  • 11 617 tis. Kč
    • •
  • 6 968 tis. Kč
    • •
  • MPO
Project

Ischaemia reperfusion injury in accute myocardial infarction (NT13709)

. Oxidative damage of DNA caused by free oxygen radicals, measurable in lymphocytes with comet assay, can establish reperfusion injury. Measurement of DNA damage in coronary......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2012 - 2014
    • •
  • 2 778 tis. Kč
    • •
  • 2 778 tis. Kč
    • •
  • MZ
Project

Mitochondrial DNA manipulations for simulation of oxidative stress (KJB500110902)

into the mitochondrial matrix of living cells such as HEPG2, HeLa, or INS1E cells, (using DNA for achievement of silencing expression of the ND5 gene of mitochondrial DNA as a prototypical mutations; and iii) access consequences of...

ED - Fyziologie

  • 2009 - 2011
    • •
  • 1 797 tis. Kč
    • •
  • 1 797 tis. Kč
    • •
  • AV ČR
Project

The use of plants in monitoring of human DNA damage. (LTC17047)

We propose to use the plants, and particularly their generally viable repair mutants, as supplemental model system to human biomonitoring by comet assay. We expect important input to interpretation of DNA damage and mutagenesis by c...

EB - Genetika a molekulární biologie

  • 2017 - 2020
    • •
  • 3 010 tis. Kč
    • •
  • 3 010 tis. Kč
    • •
  • MŠMT
Project

Oxidative damage of DNA in bone marrow cells of patients with myelodysplastic syndrome - subtype refractory anemia with or without ring sideroblasts. (NR8265)

Assessment of non-specific oxidative damage of DNA in cells of glycophorine assay combined with application of specific restriction enzymes. Assessment of malondialdehyde-adducts in DNA of glycophorin A+ and A- cells of bon...

FD - Onkologie a hematologie

  • 2005 - 2008
    • •
  • 3 477 tis. Kč
    • •
  • 3 440 tis. Kč
    • •
  • MZ
Project

Selection of functional spermatozoa using chosen biomarkers in diagnosis of male infertility (NT11083)

spermatozoa, chosen biomarkers will be compared: ubiquitination (SUTI assay), DNA fragmentation (SCSA assay), free radicals production (EPR method); sperm viability (based......

FK - Gynekologie a porodnictví

  • 2010 - 2014
    • •
  • 3 953 tis. Kč
    • •
  • 3 953 tis. Kč
    • •
  • MZ
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