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329 (0,154s) •

Project

Making drugs smarter Novel conjugable phosphorus-based linkers for targeted drug delivery (GA23-05752S)

applications, and phosphorus SI linkers cannot be conjugated to ligands for targeted drug delivery. We aim to develop conjugable, phosphorus-based SI linkers for chemoselective conjugation with biomolecul...

Organic chemistry

  • 2023 - 2025
    • •
  • 6 174 tis. Kč
    • •
  • 6 174 tis. Kč
    • •
  • GA ČR
Project

*Targeted supercancerostatics of new generation for leucemia therapy. (FT-TA2/081)

*Technology of specific ligands production development targeted for complexation of radionuclides. Ligands will be content reactive functional groups for conjugation with monoclonal antibody antiCD66. The conjugate will be applied i...

CC - Organická chemie

  • 2005 - 2008
    • •
  • 70 398 tis. Kč
    • •
  • 48 451 tis. Kč
    • •
  • MPO
Project

Multivalent glycopolymers as ligands of lectin-denoted biological targets (LTC17005)

Multivalent biocompatible polymeric conjugates with various defined in cell cultures. The affinity of glycopolymeric conjugates to lectin targets of carbohydrate ligands, their composition and the linker type. Biological st...

CE - Biochemie

  • 2017 - 2020
    • •
  • 2 791 tis. Kč
    • •
  • 2 791 tis. Kč
    • •
  • MŠMT
Project

Conjugates of nucleobases with metal complexes as electroactive markers. Application of labelled oligonucleotides in electrochemical DNA sensors (GA203/05/0043)

The project will deal with the synthesis of novel types of conjugates of purine and pyrimidine bases with metal complexes (e.g. ferrocene, transition metal complexes of bipyridine or phenanthroline etc.) connected by a conjugated

CC - Organická chemie

  • 2005 - 2007
    • •
  • 2 967 tis. Kč
    • •
  • 2 967 tis. Kč
    • •
  • GA ČR
Project

Inducing open-shell ground state in conjugated hydrocarbons (GN24-10142O)

. Then, we will form conjugated macrocycles from the viable extended indenofluorenes in linear conjugated polymers in connection with the properties of monomeric units, linkers, and spacers. In this project, we will employ ...

Physical chemistry

  • 2024 - 2027
    • •
  • 5 221 tis. Kč
    • •
  • 5 221 tis. Kč
    • •
  • GA ČR
Project

Spacer-controlled property tuning in the acceptor-imidazole-donor type of the charge-transfer chromophores (GA203/08/0076)

linkers as well as their combination allows the conjugation modulation betweenThe goal of this project is to synthesize and verify properties of the proposed donor acceptor substituted imidazoles as potential NLO active chromophore...

CC - Organická chemie

  • 2008 - 2010
    • •
  • 2 004 tis. Kč
    • •
  • 2 004 tis. Kč
    • •
  • GA ČR
Project

Development of fluoroalkylated hypervalent iodine reagents for thiol bioconjugations (GA17-00598S)

reaction rates, reversibility, low conjugate stability, or low selectivity of tagging with optional water soluble linker and a variety of functional groups, is expected to provide a portfolio of reagents for thiol conjugation

CC - Organická chemie

  • 2017 - 2019
    • •
  • 6 086 tis. Kč
    • •
  • 4 499 tis. Kč
    • •
  • GA ČR
Project

Peptide Drug Delivery Systems Targeting Macrophages for Antimycobacterial Active Compounds (GJ17-27514Y)

via various linkers. Oligotuftsin carriers that target specifically macrophages agents. All the small molecules, carriers and their conjugates will be evaluated......

FR - Farmakologie a lékárnická chemie

  • 2017 - 2019
    • •
  • 4 525 tis. Kč
    • •
  • 4 525 tis. Kč
    • •
  • GA ČR
Project

Evolution of single molecule conductance from first principles (GA19-23702S)

will focus on conjugated molecules and will explore metal-molecule chemical linkers on conductance. Such processes include ring rotation in conjugated molecules or bond......

Condensed matter physics (including formerly solid state physics, supercond.)

  • 2019 - 2022
    • •
  • 5 347 tis. Kč
    • •
  • 4 723 tis. Kč
    • •
  • GA ČR
Project

UOCHB MSCA Mobility II (EF18_070/0010562)

The project goal is to establish and implement international scientific cooperation by supporting the participation of the IOCB scientific staff at renowned foreign institutions. The project is targeted at employees whose proposal was not supported u...

Organic chemistry

  • 2018 - 2021
    • •
  • 3 669 tis. Kč
    • •
  • 3 669 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 329