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4 866 (0,129s) •

Project

Natural Killer cell based adoptive cellular immunotherapy of hemato-oncology disorders. (NU22-08-00287)

The use of natural killer (NK) cells as a cellular immunotherapy has increased for expansion and activation of NK cells from human peripheral blood mononuclear cells as well as clinical-scale method to pro...

Immunology

  • 2022 - 2025
    • •
  • 10 115 tis. Kč
    • •
  • 10 115 tis. Kč
    • •
  • MZ
Project

The role of NK and NKT cells in the pathogenesis of primary idiopathic polymyositis and dermatomyositis (NR9106)

Characterization and differentiation of subpopulations of NK and NKT cells NK/NKT cell subpopulations in peripheral blood of PM/DM patients and healthy, effect of a therapy on distribution of NK and NKT

FP - Ostatní lékařské obory

  • 2006 - 2008
    • •
  • 4 797 tis. Kč
    • •
  • 4 539 tis. Kč
    • •
  • MZ
Project

The influence of adenosine receptors on NK cells mediated antitumor immunity response. (KJB500200614)

NK cells, due to their ability of direct cytotoxic function, represent an important part of antitumor immune response. NK cells express, besides others, adenosine) inhibit NK cell cytotoxic functi...

EC - Imunologie

  • 2006 - 2008
    • •
  • 845 tis. Kč
    • •
  • 845 tis. Kč
    • •
  • AV ČR
Project

Harnessing soluble forms of NK cell receptors and their ligands for the generation of novel anticancer immunotherapeutics (GA15-15181S)

Surface receptors of natural killer (NK) and NK-T cells participate is available on the human NK cell receptors, ligands and their complexes yet to recombinantly express soluble forms of human NK ...

EC - Imunologie

  • 2015 - 2019
    • •
  • 6 313 tis. Kč
    • •
  • 6 313 tis. Kč
    • •
  • GA ČR
Project

Nanoscale organisation of NK cell receptor-ligand complexes through the optics of quantitative single-molecule microscopy (GF23-08490L)

Our knowledge of natural killer (NK) cell immune synapse formation is limited resolution, we will reconstitute live NK cell immune synapse to assess (a) oligomeric) its correlation with signal transduction and ...

Biochemistry and molecular biology

  • 2023 - 2026
    • •
  • 7 596 tis. Kč
    • •
  • 7 596 tis. Kč
    • •
  • GA ČR
Project

NK cell imunotherapy in leukemias – development and characterization of advanced therapy medicinal product. (NV15-30661A)

of humans with hemato-oncological diagnosis. NK cells are a central component of anti, but recognize damaged (transformed) cells with decreased expression of MHC I molecules. Better understanding of the NK cel...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 4 309 tis. Kč
    • •
  • 4 309 tis. Kč
    • •
  • MZ
Project

Utilization of novel mouse strains for investigation of the NK cell regulatory role in development and therapy of cancer (GA14-10100S)

Natural killer (NK) cells participate in the recognition of antigens expressed on transformed or stressed cells and in the regulation of innate and adaptive immunity. The major NK cell receptor families (N...

FD - Onkologie a hematologie

  • 2014 - 2018
    • •
  • 10 006 tis. Kč
    • •
  • 10 006 tis. Kč
    • •
  • GA ČR
Project

Structural immunology of NK cell recognition from tumor evasion to its eradication (GA25-18490S)

Structural immunology of NK cell recognition is a hot spot of research engagers or chimeric antigen receptor NK cells, respectively. In the proposed project, we will produce selected recombinant NK cel...

Microbiology

  • 2025 - 2027
    • •
  • 9 336 tis. Kč
    • •
  • 9 336 tis. Kč
    • •
  • GA ČR
Project

Exploiting molecular mechanisms of natural killer cell recognition for antitumor therapy (LUAUS25250)

, NIH, Bethesda, Maryland, USA) deals with the issue of NK cell recognition and immune surveillance at the molecular level using selected NK cell receptors and their ligands. Disturbances in NK cell

Biochemistry and molecular biology

  • 2025 - 2028
    • •
  • 9 935 tis. Kč
    • •
  • 9 935 tis. Kč
    • •
  • MŠMT
Project

Interaction of NK Potential Receptor NKR-P1 with MHC Class I Molecules - a Possible Role in NK Cell Recognition (GA310/94/1533)

9H - 9

  • 1994 - 1996
    • •
  • 830 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • GA ČR
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