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48 (0,067s) •

Project

Immunological diagnostics of autoimmune neuropathies and verification of benefit of immunomodulating therapy. (NF6348)

The purpose of the project is to introduce immunological diagnostics of acute and chronic autoimmune neuropathies in the Czech republic. It is a multicentre pilot project of detection of antibodies in serum a CSF in patients with neuropa...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2000 - 2002
    • •
  • 2 968 tis. Kč
    • •
  • 2 966 tis. Kč
    • •
  • MZ
Project

The impact of pancreas transplantation on the course of diabetic autonomic neuropathy. (NB6394)

The aim of the current project is an evaluation of the impact of a successful pancreas transplantation on the course of diabetic autonomic neuropathy. Methods used for the follow-up include a battery of cardiovascular function tests, spectra...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2000 - 2002
    • •
  • 911 tis. Kč
    • •
  • 906 tis. Kč
    • •
  • MZ
Project

Analysis of the BSCL 2 gene and a clinical study among Czech patients with hereditary motor neuropathy. (NS10552)

recently found in patients with hereditary motor neuropathy (HMN). Only patients with the pure motor neuropathy will be selected from the available database of patients withhereditary neuropathy. Selected probands will be ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2009 - 2011
    • •
  • 2 165 tis. Kč
    • •
  • 2 165 tis. Kč
    • •
  • MZ
Project

Whole genome sequencing and RNA sequencing - a tool for elucidation of the causes of rare types of hereditary neuropathies. (NV16-30206A)

Hereditary neuropathies (IPN) are a group of inherited peripheral neuropathies, which are characterized by distal muscle weakness, foot deformities and muscle in this group of patients with previously unexplained cause of hereditary...

FH - Neurologie, neurochirurgie, neurovědy

  • 2016 - 2019
    • •
  • 5 850 tis. Kč
    • •
  • 5 850 tis. Kč
    • •
  • MZ
Project

The effect of simultaneous pancreas and kidney transplantation with long term normoglycemia on small fibre diabetic neuropathy (NR7929)

Diabetic neuropathy is caused by long-term hyperglycemia and affects nerve fibres of various types. Small fibre neuropathy may be assessed by epidermal nerve fibre counts in skin biopsies. The aim of the project is the longitudinal ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2007
    • •
  • 2 229 tis. Kč
    • •
  • 1 944 tis. Kč
    • •
  • MZ
Project

Painful diabetic neuropathy (NS9667)

The project is focused on the extension of our knowledge about pathophysiology of the development and progression of peripheral neuropathy and neuropathic pain from the initial stages of diabetes mellitus type 2 (DM2). A group of patients wi...

FH - Neurologie, neurochirurgie, neurovědy

  • 2008 - 2011
    • •
  • 3 213 tis. Kč
    • •
  • 3 138 tis. Kč
    • •
  • MZ
Project

Autosomal recessive demyelinating neuropathy type CMT4C ? analysis of the SH3TC2 gene and a clinical study. (NT11521)

Defects in the SH3TC2 gene have been recently identified in patients with hereditary motor and sensory neuropathy (HMSN). Patients cohort of about 120 urelated individuals with the demyelinating hereditary neuropathy and pedigrees c...

FH - Neurologie, neurochirurgie, neurovědy

  • 2010 - 2013
    • •
  • 3 846 tis. Kč
    • •
  • 3 846 tis. Kč
    • •
  • MZ
Project

Mitochondrial optic neuropathies a complex genetic and metabolomic analysis to characterize molecular bases and to identify novel biomarkers (NU22-07-00614)

spectrum of mitochondrial disorders. Leber hereditary optic neuropathy (LHON neuropathies which usually result in legal blindness. Nowadays, more than 20 disease genes are recognized as underlying cause of mitochondrial optic n...

Biochemistry and molecular biology

  • 2022 - 2025
    • •
  • 13 769 tis. Kč
    • •
  • 13 769 tis. Kč
    • •
  • MZ
Project

The influence of ascorbic acid on phenotyp in Charcot Marie Tooth disease type 1A (NR9517)

To evaluate an influence of ascorbic acid on phenotype of CMT1A neuropathy. The cohort of sixty patients will be treated ( AA vs placebo) fot two years. The primary efficacy outcome will be an improvement on CMTNS, electro- physiological par...

FH - Neurologie, neurochirurgie, neurovědy

  • 2007 - 2010
    • •
  • 4 183 tis. Kč
    • •
  • 3 986 tis. Kč
    • •
  • MZ
Project

Detection of point mutations i Cx32, MPZ, EGR2 and PMP22 genes in patients with inherited peripheral neuropathies without 17p11.2-12 rearrangement (NF6504)

Sequencing analysis of Charcot-Marie-Tooth type 1 disorders genes Cx32, MPZ, EGR2 and PMP22 in patients from present collection of Czech patients with inherited peripheral neuropathies without the 17 p rearrangement.......

FH - Neurologie, neurochirurgie, neurovědy

  • 2001 - 2003
    • •
  • 1 138 tis. Kč
    • •
  • 1 138 tis. Kč
    • •
  • MZ
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