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1 112 (0,146s) •

Project

Development of highly effective allogenic CAR T-cells based on innovative surface proteome analysis and non-viral approaches (NW25-03-00298)

Cell therapies based on chimeric antigen receptor (CAR) T-cells represent of allogenic CAR T-cells by applying the state-of-the-art molecular, cellular, proteomic and/or immunotargets. Furthermore, we plan to devel...

Cell biology

  • 2025 - 2028
    • •
  • 16 192 tis. Kč
    • •
  • 16 192 tis. Kč
    • •
  • MZ
Project

Next generation CAR-T cells for the therapy of hematological malignancies (NU23-03-00188)

malignancies such as AML, B-ALL and B-NHL using CAR-T T lymphocytes. The aim of the project is to build on the ongoing clinical study with CD19-specific CAR-T lymphocytes, which CD19 CAR-T

Hematology

  • 2023 - 2026
    • •
  • 13 368 tis. Kč
    • •
  • 13 368 tis. Kč
    • •
  • MZ
Project

Pre-clinical validation of cGMP production of CAR T-cells for solid tumorstherapy (NV19-08-00147)

Chimeric antigen receptor (CAR) T-cell is a cutting edge technology for targeted cell therapy of oncologic diseases. Promising clinical results were reported. Here we propose to validate protocols for the production of CAR...

Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

  • 2019 - 2023
    • •
  • 14 420 tis. Kč
    • •
  • 14 420 tis. Kč
    • •
  • MZ
Project

Cellular Immunology in Renal Transplantation Frequencies of Cytotoxic T Lymphocyte Precursors as a Prognostic Marker. (IZ2027)

9F - 9

  • 1994 - 1996
    • •
  • 434 tis. Kč
    • •
  • 661 tis. Kč
    • •
  • MZ
Project

Cellular immunology in kidney transplantation - nonrestricted versus self-restricted cytotoxic T lymphocytes (IZ4198)

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1997 - 1998
    • •
  • 600 tis. Kč
    • •
  • 600 tis. Kč
    • •
  • MZ
Project

Immunomodulation in the treatment of children with frequent respiratory infections. (IZ2169)

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1994 - 1997
    • •
  • 700 tis. Kč
    • •
  • 941 tis. Kč
    • •
  • MZ
Project

New approaches to Chimeric Antigen Receptor T cells analysis of RASAL3 protein function and identification of novel CAR-T activity-modifying genes (GA22-35273S)

Chimeric Antigen Receptor (CAR) T cells achieved remarkable success in treating to the original promises. Novel designs of CAR-T cells are urgently needed with further potential for augmenting CAR-T

Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

  • 2022 - 2024
    • •
  • 8 916 tis. Kč
    • •
  • 8 814 tis. Kč
    • •
  • GA ČR
Project

The appreciacion of clinical development of opportunistic infection in the relation to immunological profile in HIV+ patients. (IZ2330)

9F - 9

  • 1994 - 1996
    • •
  • 959 tis. Kč
    • •
  • 1 209 tis. Kč
    • •
  • MZ
Project

Adoptive immunotherapy of hematological malignancies in elderly patients preclinical and clinical study (NV16-34405A)

Innovative immunotherapy approaches, such as administration of haploidentical natural killer (NK) cells with phenotype changed by cytokine induction or with molecular genetic methods, are being extensively utilized in the therapy of hematological mal...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 10 994 tis. Kč
    • •
  • 10 994 tis. Kč
    • •
  • MZ
Project

Impact of microbiome on toxicity and efficacy of antitumor therapy of hematologic malignancies (NU22-03-00370)

, PI3k inhibitors – esp. idelalisib and CAR T-cell therapy), which’s mode of action. There is however lack of almost any data on microbiome effect in the context of other T-cell......

Hematology

  • 2022 - 2025
    • •
  • 15 025 tis. Kč
    • •
  • 15 025 tis. Kč
    • •
  • MZ
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