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15 (0,071s) •

Project

Study of regulation of the cell cycle in malignant non-Hodgkins lymphomas (GP301/05/P507)

is associated with a notable increase of p21 expression. This project is mainly concentrated on the study of p21 upregulation. Alternative splicing or expression from an alternate promoter can produce variants of a gene. The tumor ...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 1 159 tis. Kč
    • •
  • 1 159 tis. Kč
    • •
  • GA ČR
Project

Molecular prognostic factors in myeloid leukemia (NC7560)

Molecular prognostic factors in patients of acute and chronic myeloid leukemia. Expression of p21 Cip, Fas, FasL, DR 4 and 5, and Wt-1 genes detected at MRNA ( comparative and real-time RT-PCR) and protein level (flow cytometry and Western b...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 4 870 tis. Kč
    • •
  • 4 796 tis. Kč
    • •
  • MZ
Project

The role of homologues, p73, p63 and KET proteins, in cell cycle, malignant transformation of the cell and apoptosis. (NC6404)

One of our major interests is to study the functions of p73alpha,p73beta,KET and p63 homologues of p53 tumour suppressor in developmental and cell cycle regulation, in tumour biology as well as functional interactions among these proteins. We will st...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 5 858 tis. Kč
    • •
  • 5 846 tis. Kč
    • •
  • MZ
Project

Biomarkers for optimization of the treatment of soft - tissue sarcomas (NM14)

,p53,p21,mdm2,bcl-2,Fas,Fasl ligand,ICE p10,apoptosis by TUNEL technique...

FD - Onkologie a hematologie

  • 1998 - 2000
    • •
  • 1 292 tis. Kč
    • •
  • 1 028 tis. Kč
    • •
  • MZ
Project

Impact of complex mixtures in polluted air on the health of risk population groups( Program Air pollution and health) (SI/340/2/00)

Genotoxicity of air - characterization of complex mixtures of organic compounds - mutagenicity, DNA adducts, embrylotoxicity - induction of p21 and p53 proteins. Exposure of model population - effect of PM2.5 and PAH - biomarkers of exposure...

DN - Vliv životního prostředí na zdraví

  • 2000 - 2002
    • •
  • 32 338 tis. Kč
    • •
  • 32 338 tis. Kč
    • •
  • MŽP
Project

The role of cytokine TGF-b1 and eicosanoids in differentiation of mammalian progenitor cells (GA524/96/1716)

of the passage trough the G1/S transition of the cell cycle (cyclins, p21, RB, c-myc, c-fos...

EB - Genetika a molekulární biologie

  • 1996 - 1998
    • •
  • 3 242 tis. Kč
    • •
  • 2 798 tis. Kč
    • •
  • GA ČR
Project

New design and exploiting nanobiosensors and nanosensors to target medicine (NANOSEMED) (KAN208130801)

of biologically important proteins (p53, p21, metallothionein, glutathion etc.) and sequences...

CG - Elektrochemie

  • 2008 - 2012
    • •
  • 32 657 tis. Kč
    • •
  • 27 753 tis. Kč
    • •
  • AV ČR
Project

The role of p53, p73 and IRF-1 proteins in regulation of the cell response do DNA damage (GA312/99/1550)

as the role of p53 and IRF-1 proteins in regulation of p21-dependent growth arrest.Our...

FD - Onkologie a hematologie

  • 1999 - 2001
    • •
  • 3 298 tis. Kč
    • •
  • 3 298 tis. Kč
    • •
  • GA ČR
Project

The determination of expression levels of DNA repair and cell cycle genes in peripheral blood lymphocytes in styrene exposed individuals. (IAA500390806)

In order to understand late stages in the cascade of human genotoxicity, expression levels in DNA repair (XRCC1, XPC) and cell cycle genes (p53, p21, bax, bcl2) will be addressed in styrene exposed and control populations. The intended proje...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 2 509 tis. Kč
    • •
  • 2 509 tis. Kč
    • •
  • AV ČR
Project

Interactions of p73 protein and its isoforms with DNA. Influences of DNA supercoiling, conformation and anticancer drugs (GP204/07/P476)

(such as p21, mdm2, bax, etc.). This project is focused on studies of the p73 DNA binding...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 1 056 tis. Kč
    • •
  • 1 056 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 15