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14 (0,087s) •

Project

Physiological role of ghrelin; the importance for clinical medicine. (NB7099)

Ghrelin is a new peptide hormone serving as a regulator of growth hormone suggest the importance of ghrelin in this sites. The project will chracterize the therapy of some disorders. We will also study the changes of ghrelin

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2002 - 2005
    • •
  • 2 901 tis. Kč
    • •
  • 2 723 tis. Kč
    • •
  • MZ
Project

Impact of ghrelin and estrogen on metabolic syndrom of female obese mice (GA303/09/0744)

ghrelin are promising substances for obesity treatment. Because ghrelin is stimulated that inhibition of ghrelin is beneficial especially in OVX mice with DIO. In these mice, we plan to follow effects of ghrelin a...

CE - Biochemie

  • 2009 - 2011
    • •
  • 4 288 tis. Kč
    • •
  • 4 288 tis. Kč
    • •
  • GA ČR
Project

Interplay between ghrelin and its novel endogenous antagonist LEAP2 possible role in the pathology of obesity (GA22-11155S)

hormone ghrelin, an endogenous antagonist, liver enriched antimicrobial peptide-2 (LEAP2) has been recently found. Ghrelin and LEAP2 bind to GHSR with a similar and young mice, effect of LEAP2 on ghrelin stimulated growth ...

Endocrinology and metabolism (including diabetes, hormones)

  • 2022 - 2024
    • •
  • 7 966 tis. Kč
    • •
  • 7 436 tis. Kč
    • •
  • GA ČR
Project

Causes of the weight gain in persons treated for thyroid dysfunction (NR7928)

The study is designed to find if hormones ghrelin and leptin are involved in the control of energy balance in patients with hyperthyroidism and hypothyroidism. To confirm the hypothesis that hormones ghrelin and leptin have an effec...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 1 524 tis. Kč
    • •
  • 1 483 tis. Kč
    • •
  • MZ
Project

Involvement of Tau in neuronal functions of ghrelin a new target for Alzheimer''s disease? (7AMB12FR011)

In this project, we propose to study the effects of ghrelin agonist and antagonists, synthesized in the Institute of Organic Chemistry and Biochemistry (the Czech team) that are potential anti-obesity compounds, on : 1- Tau phosphorylation l...

FH - Neurologie, neurochirurgie, neurovědy

  • 2012 - 2013
    • •
  • 124 tis. Kč
    • •
  • 124 tis. Kč
    • •
  • MŠMT
Project

Genetic basis of syndrome MIA (Malnutrition - Inflammation - Atherosclerosis) - complication of hemodialysis treatment (NR7958)

To characterise genotype frequencies of ghrelin, LBP and HFE genes in patients with chronic renal failure and/or syndrome MIA and in control population. To analyse, if ghrelin, LBP and HFE gene variants influence complications of he...

EB - Genetika a molekulární biologie

  • 2004 - 2008
    • •
  • 4 136 tis. Kč
    • •
  • 3 810 tis. Kč
    • •
  • MZ
Project

Environmental and genetic influence of obesity prevalence in Czech population (NR8489)

To evaluate the influence of variations in the gene for ghrelin (Arg51?Gln, Leu72?Met a Gln90?Leu) on BMI and WHR in 1% representatively selected Czech population sample. To establish whether the Arg51 ? Gln, Leu72 ? Met, and Gln90 ? Leu pol...

EB - Genetika a molekulární biologie

  • 2005 - 2006
    • •
  • 2 309 tis. Kč
    • •
  • 2 279 tis. Kč
    • •
  • MZ
Project

Postprandial response of ghrelin and other appetite-modulating hormones in patients with anorexia nervosa and bulimia nervosa (NR9158)

In the project we will examine the relationship of selected food intake regulating hormones: ghrelin (acyl, desacyl, total), cholecystokinin, leptin, NPY, insulin and recently discovered obestatin in patients with anorexia nervosa a bulimia ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 6 072 tis. Kč
    • •
  • 6 015 tis. Kč
    • •
  • MZ
Project

Nutritional modulation of adjuvant arthritis in rats interplay of leptin and ghrelin (GA305/06/0427)

-directional immune-endocrine interactions. Leptin and ghrelin, both food intake-regulating) The temporal pattern of the expression and secretion of leptin and secretion of ghrelin, IL......

ED - Fyziologie

  • 2006 - 2008
    • •
  • 2 197 tis. Kč
    • •
  • 2 197 tis. Kč
    • •
  • GA ČR
Project

Modulations of mesolimbic ghrelin signalling – a new hope for methamphetamine addiction treatment? (GA21-30795S)

Methamphetamine addiction is a serious public health problem, treatment remains exclusively symptomatic with low relapse prevention. The ghrelin/GHS-R1A antagonism represents a promising mechanism for drug addiction treatment. The GHS-R1A an...

Substance abuse

  • 2021 - 2023
    • •
  • 5 464 tis. Kč
    • •
  • 5 464 tis. Kč
    • •
  • GA ČR
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