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361 (0,114s) •

Project

Innovative preparation and verification of CDK and GSK kinases (FW02020128)

The main goal of the project is the design and synthesis of new, innovative, safety components that use as inhibitory cyclin-dependent kinases (CDKs) and glycogen synthase kinases (GSKs) that can be used in combat, schizoph...

Organic chemistry

  • 2020 - 2023
    • •
  • 5 352 tis. Kč
    • •
  • 4 125 tis. Kč
    • •
  • TA ČR
Project

Evaluation of cyclin-dependent kinase inhibitors in cancer cell lines with specific genetic alterations (GAP305/12/0783)

Synthetic inhibitors of cyclin-dependent kinases (CDK) have been developed experiences with the development of CDK inhibitors, including synthesis, biochemical application is to study molecular mechanisms of action of our n...

CE - Biochemie

  • 2012 - 2014
    • •
  • 5 873 tis. Kč
    • •
  • 5 873 tis. Kč
    • •
  • GA ČR
Project

Modulation of cell division of normal and cancer cells by cyclin-dependent kinase inhibitors (GA301/08/1649)

Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA transcription. A variety of genetic events cause universal overactivity of the cell cycle cdks in human cancers, ant their inhibition...

FD - Onkologie a hematologie

  • 2008 - 2012
    • •
  • 6 985 tis. Kč
    • •
  • 6 985 tis. Kč
    • •
  • GA ČR
Project

Regulation of mitosis by WEE1 inhibitory kinase in the green alga Chlamydomonas reinhardtii (IAA500200614)

kinases (CDKs) in complex with mitotic cyclins. These CDK complexes must be kept the key decision about mitosis is done prior it. A family of tyrosine kinases named WEE1 is responsible for inactivation of CDKs...

EB - Genetika a molekulární biologie

  • 2006 - 2010
    • •
  • 4 457 tis. Kč
    • •
  • 4 457 tis. Kč
    • •
  • AV ČR
Project

Chemical genetic analysis of role of cyclin-dependent kinases in cancer cell lines (GJ15-17282Y)

Cyclin-dependent kinases (CDKs) are universal eukaryotic protein regulators that promote cell cycle, initiation of DNA replication, and mitosis. Why CDKs/cyclins of CDK1-cyclin B complex can be overcome by modulating CD...

CE - Biochemie

  • 2015 - 2017
    • •
  • 3 665 tis. Kč
    • •
  • 3 665 tis. Kč
    • •
  • GA ČR
Project

The effect of cyclin dependent kinase on chloroplast division in green algae of genera Chlamydomonas and Scenedesmus (KJB5020305)

on the activity of cyclin-dependent kinases (CDK) during cell cycle of algae dividing investigating the functional relation of plastokinesis on CDK, attention will be paid rings in the plastid division plane and that could...

EA - Morfologické obory a cytologie

  • 2003 - 2005
    • •
  • 2 408 tis. Kč
    • •
  • 2 060 tis. Kč
    • •
  • AV ČR
Project

Inhibitors of cyclin-dependent kinases (cdc 2, cdk 2) derived from olomoucine (GA301/96/0437)

CE - Biochemie

  • 1996 - 1996
    • •
  • 0 tis. Kč
    • •
  • 1 956 tis. Kč
    • •
  • GA ČR
Project

Interplay between cdk kinase and MAP kinase pathway during maturation of oocytes and their fertilization - a model for cell cycle control in somatic and maligna (ME 189)

, specific role of cdk1 and cdk2 kinases and their regulattory subunits - cyclins A and B aswell as MAP and MEK kinase at meiotic checkpoints wil be established* MERGEFIELD......

ED - Fyziologie

  • 1998 - 2001
    • •
  • 1 750 tis. Kč
    • •
  • 1 050 tis. Kč
    • •
  • MŠMT
Project

New kinase inhibitors to treat acute myeloid leukemia (NV15-28951A)

kinases may be more efficacious. We have identified new compounds with dual specificity towards the FLT3 and CDK kinases that are structurally unrelated to other tyrosine kinase have promise but exhibit limited ef...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 10 476 tis. Kč
    • •
  • 10 476 tis. Kč
    • •
  • MZ
Project

Regulation of gene expression by a new mRNA-binding factor (GA16-10930S)

. Trancriptional cyclin-dependent kinases (tCDK) play a crucial role in the regulation of gene, making it the first mRNA-binding CDK. We hypothesize that the mRNA-binding activity of the CDK plays an important and unrecogni...

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 9 396 tis. Kč
    • •
  • 9 396 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 361