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313 (0,137s) •

Project

Optimization of cystic fibrosis patient-derived cellular models to asses restoration of CFTR function in patients with cystic fibrosis (NU23-07-00079)

of therapeutic response differs among patients with the identical CFTR genotype. Intestinal epithelial cells highly expressing CFTR and a derived model of intestinal organoids in air-liquid interface (ALI) and nasal or...

Paediatrics

  • 2023 - 2026
    • •
  • 15 195 tis. Kč
    • •
  • 15 195 tis. Kč
    • •
  • MZ
Project

Intestinal organoids as an in-vitro model for predicting the response to therapies correcting molecular defects in cystic fibrosis (NU20-07-00049)

by using a intestinal organoids that are obtained from rectal biopsies. The proposed project aims to set organoids from the Czech CF patients who carry the most common from organoids at the extremes of responses t...

Paediatrics

  • 2020 - 2023
    • •
  • 11 461 tis. Kč
    • •
  • 11 461 tis. Kč
    • •
  • MZ
Project

Transformations of the gastrointestinal stem cell niche during the development and regeneration (GA21-26025S)

of colon cancer and intestinal regeneration. Additionally, intestinal epithelial stem the transformation of the embryonic intestinal epithelial stem cells to adult ones at the level of the intestinal stem cell nic...

Cell biology

  • 2021 - 2023
    • •
  • 8 487 tis. Kč
    • •
  • 8 487 tis. Kč
    • •
  • GA ČR
Project

The canonical Wnt pathway components involved in non-canonical signaling mechanisms (GA18-26324S)

in the adult colon, colon cancer, and intestinal regeneration will be characterized using transgenic mouse models, intestinal organoid cultures, and xenografts. The results will be employed to identify the composition of L...

Cell biology

  • 2018 - 2022
    • •
  • 9 615 tis. Kč
    • •
  • 8 721 tis. Kč
    • •
  • GA ČR
Project

Pushing the limits of the cellular plasticity in the intestinal epithelium by altering the cellular fates of differentiated cells (GA25-17207S)

The cellular plasticity connected to re-activated embryonic gene expression allows the intestinal epithelial cells to face epithelial damage. On the other hand molecular mechanisms driving the cellular plasticity of the intestinal e...

Cell biology

  • 2025 - 2027
    • •
  • 11 806 tis. Kč
    • •
  • 11 806 tis. Kč
    • •
  • GA ČR
Project

Wnt ligands and Wnt-secreting cells for intestinal homeostasis, regeneration and colon cancer a complex world beyond the cancer-activating mutation (GA18-21466S)

of most abundant, but also most enigmatic ligand Wnt5a for intestinal renewal...

Developmental biology

  • 2018 - 2022
    • •
  • 8 406 tis. Kč
    • •
  • 7 632 tis. Kč
    • •
  • GA ČR
Project

Development of an in vitro model for the study of renal dysfunction due to pharmacotherapy (NU23-06-00045)

Renal organoids represent a modern technique enabling to study the response to pharmacotherapies in a multicellular context. The organoids make possible the unlimited and validate the technique of renal cortex organoids, id...

Urology and nephrology

  • 2023 - 2026
    • •
  • 14 342 tis. Kč
    • •
  • 14 342 tis. Kč
    • •
  • MZ
Project

Integration of novel RNA-nanotherapeutics in patient-derived breast cancer organoids (NU23J-08-00035)

nanoparticles will be optimized with the use of patient-derived breast cancer organoids history. Furthermore, thanks to the implementation of the organoids in advanced organ markers characteristic of the tumor development of each <...

Biochemistry and molecular biology

  • 2023 - 2026
    • •
  • 6 894 tis. Kč
    • •
  • 6 894 tis. Kč
    • •
  • MZ
Project

Retinal Organoids Exploring the Effects of Photo-Stimulation on Human Retina (GA21-08182S)

Pluripotent stem cell-derived retinal organoids represent a reliable experimental retinal model, and also potential source for cell replacement therapy for treating retinal dystrophies. However, in vitro generated retinal cells are often for...

Cell biology

  • 2021 - 2023
    • •
  • 5 514 tis. Kč
    • •
  • 5 514 tis. Kč
    • •
  • GA ČR
Project

A humanized organoid-based platform for stroke modelling and mRNA-based therapeutic intervention (GA24-11364S)

technologies, disease modeling using brain organoids and mRNA-based therapeutic propose to combine these cutting-edge technologies and apply the brain organoids......

Neurosciences (including psychophysiology)

  • 2024 - 2026
    • •
  • 10 693 tis. Kč
    • •
  • 10 693 tis. Kč
    • •
  • GA ČR
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