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21 (0,101s) •

Project

Generation of high throughput in vitro models based on reporter gene assays for toxicological and environmental application (GA16-07544S)

(PPARs) and their heterodimeric partner retinoid X receptor alpha (RXR-alpha) are very often target of EDCs. PPARs play crucial role in lipid and glucose metabolism and disturbing of PPARs signaling leads to serious diseas...

DN - Vliv životního prostředí na zdraví

  • 2016 - 2018
    • •
  • 4 691 tis. Kč
    • •
  • 4 691 tis. Kč
    • •
  • GA ČR
Project

The role of PPAR-alfa in the regulation of insulin sensitivity. (NB7429)

The aim of the project is to study the role of PPAR-alfa in the regulation of glucose metabolism and insulin sensitivity. Euglycemic-hyperinsulinemic clamp will be used to measure the changes of insulin sensitivity in patients with insulin w...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
    • •
  • 3 134 tis. Kč
    • •
  • 3 035 tis. Kč
    • •
  • MZ
Project

The study of antitumor activity of synthetic ligands of PPARs on glioblastoma cell lines and on explants of glial tumors of brain (NR8370)

To find if selected synthetic ligands of PPARs (ciglitazone, etc.) affect growth and differentiation of cell explants of glial tumors. Analysis of effect of PPAR antagonists (Diclofenac, Nimesulid, MK 886, etc.) on proliferation and...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 2 915 tis. Kč
    • •
  • 2 215 tis. Kč
    • •
  • MZ
Project

Complexes of selected transition metals with plant-derived compounds with anti-NF-kappa B and pro-PPAR dual activities (GF21-38204L)

nuclear receptors PPAR. This project aims to obtain secondary metabolites of medicinal plants, especially prenylated phenols, with dual anti-NFκB and pro-PPAR activity will be evaluated based on their ability to inhibit NFκB and st...

Inorganic and nuclear chemistry

  • 2021 - 2023
    • •
  • 9 028 tis. Kč
    • •
  • 9 028 tis. Kč
    • •
  • GA ČR
Project

Fatty acid- and glucose-induced changes in gene expression of peroxisome proliferator-activated receptor (PPAR) signalling cascade molecules (OC 153)

investigation of effects of major energetic substrates on gene expression of major molecular components of signalling molecules...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2010
    • •
  • 2 910 tis. Kč
    • •
  • 1 895 tis. Kč
    • •
  • MŠMT
Project

New mechanisms of platinum-based drug action as a tool for anticancer therapeutic strategies (NT11201)

The project aims to improve our understanding of novel mechanisms of the effects of platinum (Pt) cytostatics, PPAR? ligands and their combinations at both molecular and cellular level. We will analyze specific genes and proteins regulating ...

FD - Onkologie a hematologie

  • 2010 - 2014
    • •
  • 7 664 tis. Kč
    • •
  • 7 664 tis. Kč
    • •
  • MZ
Project

The role of peripheral metabolism of glucocorticoids in inflammation-induced changes in humans and animal model of inflammatory bowel disease (NR8576)

-up. Receptors of PPAR gama could modulate expression of 11HSD...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2005 - 2007
    • •
  • 3 732 tis. Kč
    • •
  • 3 607 tis. Kč
    • •
  • MZ
Project

Tissue resistance to insulin action - underlying mechanisms and possibilities of nutritional and pharmacological intervention (NB6678)

, activation of PPAR transcription factors, and expression of lipoprotein and hormone...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 3 823 tis. Kč
    • •
  • 3 592 tis. Kč
    • •
  • MZ
Project

Pharmacological modification of potential signals in adipocytes and hepatocytes that are involved in lipid metabolism and implications in obesity (NL7418)

, PPARs modulators with pharmacological intervention. Pharmacological modulation...

FR - Farmakologie a lékárnická chemie

  • 2003 - 2005
    • •
  • 2 603 tis. Kč
    • •
  • 2 551 tis. Kč
    • •
  • MZ
Project

Interaction of diatery factors with some single genetic polymorphisms in pathogenesis of atherogenic dyslipidemias with hyperapolipoproteinemia B-100 (NR8149)

Group of 240 patients with aterogenic dyslipidemia (with hyper apoB100)will be examined for plasma lipids, lipoproteins, single nucleotide polymorphisms of MTP, FABP-2, PPAR-gamma-2, dietary composition, cholesterol absorption and synthesis....

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 2 941 tis. Kč
    • •
  • 2 433 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 21