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49 (0,176s) •

Project

Glycan-dependent regulation of NK cell recognition structural biology and novel methods of glycopeptide analysis (LTC20078)

Project aims: Structure and glycan-dependent binding of selected human natural killer (NK) cell receptors to their newly described ligands will be studied by means of integrative structural biology and biochemistry. Systematic study of HILIC retentio...

Biochemistry and molecular biology

  • 2020 - 2023
    • •
  • 3 998 tis. Kč
    • •
  • 3 998 tis. Kč
    • •
  • MŠMT
Project

Phototermal interactions at the microscale (GPP205/12/P868)

The activities planned in this project address theoretically and experimentally the multidisciplinary problem of heat generation by light absorption, transfer of momentum from light to submicron sized particles and thermal interaction between micropa...

BH - Optika, masery a lasery

  • 2012 - 2016
    • •
  • 1 245 tis. Kč
    • •
  • 1 245 tis. Kč
    • •
  • GA ČR
Project

Intrinsic properties of RAD51 filament and its biological regulations (GA17-17720S)

-factors. Through the integration of real-time kinetic measurements, microscale thermophoresis, structural visualization studies, conformational dynamics, and validation......

CE - Biochemie

  • 2017 - 2019
    • •
  • 9 372 tis. Kč
    • •
  • 8 937 tis. Kč
    • •
  • GA ČR
Project

HMGB1 protein involvement in nucleosome dynamics and transcription factors binding (GA15-01354S)

Storage of eukaryotic DNA in nuclei requires tightly coiling and compaction in the form of chromatin (an array of nucleosomes stabilized by histone H1). Access of regulatory factors to their specific DNA binding sites is achieved by loosening/disrupt...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 4 844 tis. Kč
    • •
  • 4 844 tis. Kč
    • •
  • GA ČR
Project

Modulation of structural and functional properties of the HSP90 chaperone machinery by reversible acetylation (GA21-31806S)

Heat shock protein 90 (HSP90) is a molecular chaperone regulating cellular proteostasis and its functions are modulated by a host of post-translational modifications, including lysine acetylation. Biological data suggest that histone deacetylase 6 (H...

Biochemistry and molecular biology

  • 2021 - 2023
    • •
  • 9 135 tis. Kč
    • •
  • 9 135 tis. Kč
    • •
  • GA ČR
Project

Unravelling the involvement of PRP8 in mRNA splicing during embryonic development and thermoresponse. (GA22-29717S)

Isoforms generated by alternative splicing (AS) expand the repertoire of a cell to adapt to various stress. How AS adapt the embryos to increase heat-tolerance and produce viable seeds is unknown. This project will investigate novel function of mRNA ...

Cell biology

  • 2022 - 2024
    • •
  • 12 551 tis. Kč
    • •
  • 12 455 tis. Kč
    • •
  • GA ČR
Project

Utilization of integrative molecular biophysical approaches for the functional studies of human natural killer cell receptors and formation of their complexes with tumour ligands (LTC17065)

Receptors of natural killer (NK) cells may trigger the lysis of virally infected or tumour cells. Utilizing integrative molecular biophysical approaches, we aim to characterize complex formation for selected immunoreceptors of human NK cells with the...

BO - Biofyzika

  • 2017 - 2020
    • •
  • 3 751 tis. Kč
    • •
  • 3 751 tis. Kč
    • •
  • MŠMT
Project

Two-dimensional separation techniques for microscale bioanalysis (GP203/09/P485)

combining focusing and separation effects. Application field for 2D microscale...

CB - Analytická chemie, separace

  • 2009 - 2011
    • •
  • 690 tis. Kč
    • •
  • 690 tis. Kč
    • •
  • GA ČR
Project

Urbanization of weather forecast, air-quality prediction and climate scenarios for Prague (UH0383)

option, and iv) microscale studies for hot-spots, using LES to test eventual measures...

Meteorology and atmospheric sciences

  • 2018 - 2020
    • •
  • 28 190 tis. Kč
    • •
  • 25 370 tis. Kč
    • •
  • KHP
Project

Urban canopy data set collection and development (OC 113)

improvement of procedure of validation of meteorological models describing processes of microscale size for forecasting of field flowing and transport processes in urban aglomeration......

DG - Vědy o atmosféře, meteorologie

  • 2006 - 2009
    • •
  • 2 537 tis. Kč
    • •
  • 1 410 tis. Kč
    • •
  • MŠMT
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