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14 082 (0,121s) •

Project

Development of nanoparticle-based cytostatics and enzymes for enhanced chemotherapy of human neuroblastomas and study of mechanisms of their action (GA14-18344S)

of cytostatic efficacies of these newly prepared drug- and enzyme-based nanoparticles used, etoposide, ellipticine, valproate, trichostatin A) in nanotransporters (based to destroy neuroblastomas than par...

CE - Biochemie

  • 2014 - 2016
    • •
  • 9 130 tis. Kč
    • •
  • 9 103 tis. Kč
    • •
  • GA ČR
Project

Combinatorial and rational approaches for the synthesis and evaluation of novel modified nucleosides with cytostatic and antimicrobial activity (GAP207/11/0344)

By combining of systematic synthesis of derivatives and analogues of active compounds, combinatorial approaches and rational design, we propose to device and prepare series of novel nucleoside derivatives and screen them for cytostatic and a...

CC - Organická chemie

  • 2011 - 2015
    • •
  • 24 168 tis. Kč
    • •
  • 24 168 tis. Kč
    • •
  • GA ČR
Project

The study of sarcosine metabolism and its participation in prostate cancer development (GA16-18917S)

and in changes in its levels and activities of enzymes involved in its metabolism affect of these enzymes and levels of sarcosine in prostate cancer cells under conditions analogous and activities of enzymes participating ...

CE - Biochemie

  • 2016 - 2018
    • •
  • 10 952 tis. Kč
    • •
  • 10 505 tis. Kč
    • •
  • GA ČR
Project

Rational design of phosphatidylinositol 4-kinase IIalpha inhibitors as tools for chemical biology and potential therapeutics (GA15-09310S)

and preparation of novel inhibitors of PI4KIIa based on a new crystal structure of this enzymePhosphatidylinositol 4-kinase IIalpha (PI4KIIa) is an enzyme which belongs on the bases of profiling against all human ...

CC - Organická chemie

  • 2015 - 2017
    • •
  • 5 104 tis. Kč
    • •
  • 5 104 tis. Kč
    • •
  • GA ČR
Project

*Novel polyfunctional hybrid polymers from renewable and recyclable raw materials with potential utilization of enzyme catalysts and nanoparticles. (2A-2TP1/135)

will be carried out in the presence of standard and enzyme biocatalysts, and willinclude with nanoparticles. The new types of monomers and polymers will be used for development......

CD - Makromolekulární chemie

  • 2007 - 2011
    • •
  • 22 464 tis. Kč
    • •
  • 13 020 tis. Kč
    • •
  • MPO
Project

Novel Cytostatics Based on Acyclic Nucleotide Analogg (GA203/93/0117)

CE - Biochemie

  • 1993 - 1995
    • •
  • 355 tis. Kč
    • •
  • 710 tis. Kč
    • •
  • GA ČR
Project

Preparation of Porous Materials by Controlled Assembly of Nanoparticles (GA16-22997S)

The project deals with synthesis of porous materials with desired porosity, pore sizes, good pore accessibility and tunable mechanical stability. A bottom up approach using a controlled assembly of polymeric nanoparticles and a locking step ...

CI - Průmyslová chemie a chemické inženýrství

  • 2016 - 2018
    • •
  • 6 056 tis. Kč
    • •
  • 5 678 tis. Kč
    • •
  • GA ČR
Project

Influence of metallothionein on binding of platinum cytostatics to DNA in cancer cells (NV15-28334A)

The objective of the project is to study the binding of platinum cytostatics for study of Pt-DNA and Pt-MT complexes. Liposome based transporter carrying platinum cytostatics, as well as carrying MTs and/or zinc ions that c...

FD - Onkologie a hematologie

  • 2015 - 2019
    • •
  • 15 620 tis. Kč
    • •
  • 15 620 tis. Kč
    • •
  • MZ
Project

Chemistry for application in biology and medicine (KSK2055603)

and cytostatics (nucleosides, nucleotides, their acyclic analogues, modified oligoribo, selective alterations of their interactions with receptors and enzymes, peptides and tissues. Investigation of structure and function of en...

CC - Organická chemie

  • 1996 - 2000
    • •
  • 183 472 tis. Kč
    • •
  • 77 505 tis. Kč
    • •
  • AV ČR
Project

Novel cytostatics based on acyclic nucleotide analogs Mode of action (IAA455402)

9J - 9

  • 1994 - 1996
    • •
  • 441 tis. Kč
    • •
  • 679 tis. Kč
    • •
  • AV ČR
  • 1 - 10 out of 14 082