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24 (0,082s) •

Project

The impact of cytidine metabolic pathways on cytarabine therapy of hematological malignancies and new diagnostic tools for their analysis (NU22-08-00148)

Cytidine deaminase (CDA) and deoxycytidine monophosphate deaminase (DCTD), deoxycytidine kinase (dCK), 5'-nucleotidase and human equilibrative nucleoside transporter (hENT1) participate in the regulation o...

Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

  • 2022 - 2025
    • •
  • 10 318 tis. Kč
    • •
  • 10 318 tis. Kč
    • •
  • MZ
Project

Alternative pathway of cytokinin catabolism (GA522/06/0022)

of these compounds is via adenine deaminase (EC 3.5.4.2) that hydrolytically converts adenine to hypoxanthine, or AMP deaminase (EC 3.5.4.6) that converts AMP to IMP. These are few......

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 3 132 tis. Kč
    • •
  • 3 132 tis. Kč
    • •
  • GA ČR
Project

Adenosine deaminase homologs in Drosophila (IAA5007107)

Members of the ADA (adenosine deaminase) gene family, which include ADA and CECR1 (cat eye syndrome critical region 1), cause severe congenital disorders in humans, however, the exact physiological role of these genes is not known. To gain, ...

EB - Genetika a molekulární biologie

  • 2001 - 2005
    • •
  • 3 878 tis. Kč
    • •
  • 1 998 tis. Kč
    • •
  • AV ČR
Project

Targets and consequences of activation-induced cytidine deaminase-mediated mutagenesis in tumours (GN24-11338I)

Activation-induced cytidine deaminase (AID) causes mutations in immunoglobulin genes of activated B cells and is required for the production of high-affinity antibodies. However, AID also causes mutations in non-immunoglobulin genes, contrib...

Cell biology

  • 2024 - 2027
    • •
  • 6 323 tis. Kč
    • •
  • 6 323 tis. Kč
    • •
  • GA ČR
Project

Adenosine deaminase Growth Factors (ME 549)

We perform a collaborative research with the laboratory of supplemental to that funded by the National Science Foundation in a research grant (proposal No. 0091348 "Adenosine Deaminase-related Growth Factors") to Dr. Peter Bryant, Developmen...

EB - Genetika a molekulární biologie

  • 2002 - 2003
    • •
  • 870 tis. Kč
    • •
  • 440 tis. Kč
    • •
  • MŠMT
Project

Drosophila model of adenosine deaminase deficiency (GA204/04/1205)

Adenosine deaminase (ADA) is a metabolic enzyme that catalyzes the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine. It is present in all organisms including bacteria. Mutations in the ADA gene that result...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 2 785 tis. Kč
    • •
  • 2 785 tis. Kč
    • •
  • GA ČR
Project

Novel oligonucleotides containing nonisosteric, enzyme-stable phosphonate linkages systematic physico-chemical study on structure variants (GA203/01/1166)

The project is directed towards a thorough study on the synthesis and physico-chemical investigation of isopolar, nonisosteric, adenine-containing dinucleoside monophosphate and oligothymidylate analogs with the enzymatically stable phosphon...

CC - Organická chemie

  • 2001 - 2003
    • •
  • 8 501 tis. Kč
    • •
  • 4 537 tis. Kč
    • •
  • GA ČR
Project

Novel Tools for Cell Cycle Analysis (TA03010719)

The determination of the cell proliferation activity is a basic methodological approach for the evaluation of the cell population conditions in many situations e.g. in the evaluation of the genotoxicity or in the analysis of the effect of agents with...

EI - Biotechnologie a bionika

  • 2013 - 2015
    • •
  • 9 600 tis. Kč
    • •
  • 6 000 tis. Kč
    • •
  • TA ČR
Project

Improving plant utility characters through changes in ethylene metabolism (GA521/99/D098)

-1aminocyclopropane-1-carboxylate (ACC) by PGPR enzyme ACC-deaminase. The decreasing of ethylene with thePGPR gene for ACC deaminase, by using of artificial inhibitors of the plant enzyme......

GC - Pěstování rostlin, osevní postupy

  • 1999 - 2002
    • •
  • 652 tis. Kč
    • •
  • 652 tis. Kč
    • •
  • GA ČR
Project

Mechanisms underlying modulation of immune cell functions by cAMP (GA310/08/0447)

This project aims at deciphering the signaling pathways by which cAMP modulates immune system functions and provokes impairment of anti bacterial immunity. We found that elevation of cytosolic cAMP in macrophages causes rapid disorganization of actin...

EC - Imunologie

  • 2008 - 2012
    • •
  • 10 247 tis. Kč
    • •
  • 10 247 tis. Kč
    • •
  • GA ČR
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