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Project

Flavonoid derivatives as standards for in vitro colon models (LUC25026)

The aim of the project is to 1. Synthetize a library of commercially unavailable flavonoids 2. Prepare sulfated and glucuronidated metabolites of both flavonoids and their break-down products 3. Enzymatically produce depsides de...

Biochemistry and molecular biology

  • 2025 - 2028
    • •
  • 7 860 tis. Kč
    • •
  • 7 860 tis. Kč
    • •
  • MŠMT
Project

Carotenoids and flavonoids interactions and hybrid antioxidants (LTC17009)

Metabolic alteration of carotenoids and their interactions with flavonoids will be investigated. Supramolecular hybrid antioxidants based on carotenoids and flavonoids will be prepared by the enzymatic and chemical methods. Their an...

CC - Organická chemie

  • 2017 - 2020
    • •
  • 2 693 tis. Kč
    • •
  • 2 693 tis. Kč
    • •
  • MŠMT
Project

Antioxidative properties of flavonoids with respect to the oxidative burst of phagocytes and cooperation between phagocytes and endothelial cells (IAB6004204)

The major aim of the project is to test the hypothesis that flavonoids do communication with endothelial cells. Antioxidative properties of selected flavonoids and endothelialcells (HUVEC) after co-incubation with flavonoids

ED - Fyziologie

  • 2002 - 2004
    • •
  • 3 395 tis. Kč
    • •
  • 1 609 tis. Kč
    • •
  • AV ČR
Project

Development of advanced analytical methods for evaluation of metabolism of natural flavonoids (GA17-05409S)

and pharmacokinetics of selected flavonoids will be developed in this project. The emphasis will be put on flavonoids present in food. Non-targeted approaches using UHPLC-HRMS of flavonoid metabolites in plasma and thus to...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2017 - 2019
    • •
  • 6 870 tis. Kč
    • •
  • 6 870 tis. Kč
    • •
  • GA ČR
Project

Chemoenzymatic preparation and biological activity of metabolites of food polyphenols (GA23-04654S)

Plant polyphenols, and particularly flavonoids belong among the most important dietary intake of flavonoids on human health, but mechanisms of action often remain that metabolites of flavonoids are responsible and/or contri...

Organic chemistry

  • 2023 - 2025
    • •
  • 10 110 tis. Kč
    • •
  • 10 110 tis. Kč
    • •
  • GA ČR
Project

Elucidation of the mechanism of flavonoid-dependent cardioprotection and changes in the bioenergetic status of the cell (GAP301/11/0662)

of heart research. Flavonolignans, a group of flavonoid derivatives, constitute a class players in the pathophysiology of cardioprotection, but the link between flavonoid of this research is to uncover the mechanisms by which flavo...

CE - Biochemie

  • 2011 - 2014
    • •
  • 6 595 tis. Kč
    • •
  • 6 595 tis. Kč
    • •
  • GA ČR
Project

Cardiovascular effects of flavonoid metabolites and the impact of metabolic risk factors (NU21-02-00135)

Higher intake of flavonoids is associated with decreased mortality from cardiovascular diseases (CD). The bioavailability of parent flavonoids is, however, low metabolites. Moreover, consumption of flavonoids in the Czech R...

Nutrition, Dietetics

  • 2021 - 2024
    • •
  • 13 850 tis. Kč
    • •
  • 13 575 tis. Kč
    • •
  • MZ
Project

Flavonoids as a unique class of carbon monoxide photoreleasable molecules (GA21-01799S)

. Some flavonoids, polyphenolic compounds found in virtually all plant tissues, which as synthetically prepared (modified) flavonoids as potential photoCORMs will be studied as photoCORMs. The chemopreventive/therapeutic activity of...

Organic chemistry

  • 2021 - 2023
    • •
  • 10 059 tis. Kč
    • •
  • 9 898 tis. Kč
    • •
  • GA ČR
Project

Effect of UV-B radiation on polyamine metabolism and accumulation of hydroxycinnamates and flavonoids in Norway spruce. (LD13051)

The aim of the project is to evaluate the alterations in polyamine biosynthetic enzymes and polyamine contents and the levels of hydroxycinnamic acids and flavonoids after the exposure of embryogenic tissue cultures of Norway spruce to UV-B ...

EF - Botanika

  • 2013 - 2014
    • •
  • 650 tis. Kč
    • •
  • 650 tis. Kč
    • •
  • MŠMT
Project

Exploring α-L-rhamnosyl-β-D-glucosidases — emerging enzymes in food chemistry (GA19-00091S)

of the flavonoid aglycon and the disaccharide rutinose, have interesting biological...

Agricultural biotechnology and food biotechnology

  • 2019 - 2023
    • •
  • 4 411 tis. Kč
    • •
  • 4 411 tis. Kč
    • •
  • GA ČR
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