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3 292 (0,08s) •

Project

Characterization of MAGE proteins cofactors for E3 ubiquitin ligases? (IAA501630902)

, Nse1 isa putative RING finger E3 ubiquitin ligase, there are two other reports of MAGE proteins interacting with RING-finger proteins. In addition, our structure for and analyze new RING

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 2 893 tis. Kč
    • •
  • 2 893 tis. Kč
    • •
  • AV ČR
Project

Role of Nse1/Nse3/Nse4, E3-ubiquitin ligase, in genome stability (GA18-02067S)

Nse1 subunit contains RING-finger domain typical for E3-ubiquitin ligases...

Cell biology

  • 2018 - 2022
    • •
  • 7 276 tis. Kč
    • •
  • 6 790 tis. Kč
    • •
  • GA ČR
Project

Recognition of DNA modified by antitumor platinum and ruthenium complexes by zinc-finger proteins and topoisomerases (KJB400040601)

This application proposes to examine efficiency of various conventional and novel antitumor platinum and ruthenium coordination complexes to eject zinc from zinc finger proteins and whether this replacement affects binding affinity ...

CE - Biochemie

  • 2006 - 2008
    • •
  • 1 764 tis. Kč
    • •
  • 1 764 tis. Kč
    • •
  • AV ČR
Project

Deciphering biological role of ZNF644 to edit the activity of G9a/GLP methylation complex (GA19-21696S)

ZNF644 and WIZ, two zinc fingers, interact with G9a/GLP complex and mediate H3K9 methylation, resulting in specific gene repression. Although G9a and GLP have been studied extensively, the interaction between these proteins and othe...

Human genetics

  • 2019 - 2023
    • •
  • 8 826 tis. Kč
    • •
  • 7 956 tis. Kč
    • •
  • GA ČR
Project

Predictive Data Modeling for Effective Gene Therapy and Bone Marrow Transplantation (ME10047)

The goal of the project is to create and validate statistical, relational-logic and combined classification models for the prediction of interaction of proteins (mainly zinc-fingers) with DNA, and thus enable to improve the outcomes...

IN - Informatika

  • 2010 - 2012
    • •
  • 1 334 tis. Kč
    • •
  • 1 334 tis. Kč
    • •
  • MŠMT
Project

Molecular basis for site-specific read-out of histone H3K4me2 by the Set3 PHD finger (GA15-17670S)

as the Set3 PHD finger domain lacks the key residues forming aromatic cage that is known...

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 8 040 tis. Kč
    • •
  • 8 040 tis. Kč
    • •
  • GA ČR
Project

Structure and function of sensor domain of proteinkinase StkP and its relationship to cellular processes (GAP207/12/1568)

PknB-like protein kinases make up a distinct family of signaling proteins extracellular PASTA domains (penicillin-binding protein and Ser/Thr kinase associated domains). PASTA domains are found in penicillin-binding pro...

CE - Biochemie

  • 2012 - 2015
    • •
  • 4 374 tis. Kč
    • •
  • 4 374 tis. Kč
    • •
  • GA ČR
Project

Identification and structural characterization of novel NPL4 inhibitors and insight into its mode of action (GA20-28685S)

Inhibition of protein degradation via ubiquitin-proteasome system is promising approach to treat cancer as documented by activity of bortezomib against multiple used to treat alcoholism, supress cancer cell growth via inhibition of NPL4 ...

Cell biology

  • 2020 - 2022
    • •
  • 7 677 tis. Kč
    • •
  • 7 677 tis. Kč
    • •
  • GA ČR
Project

Rolled rings technology for production of bearing rings with dimension about 1 - 2 m. (FI-IM/176)

Using of rolled rings technology for the production of bearing rings copying future product with dimension 1000 - 2000 mm....

JP - Průmyslové procesy a zpracování

  • 2004 - 2005
    • •
  • 15 151 tis. Kč
    • •
  • 5 171 tis. Kč
    • •
  • MPO
Project

The role of Plzf (Promyelocytic leukemia zinc finger) gene in the pathogenesis of cardiovascular and metabolic disturbances in rat models (GAP301/10/0756)

Promyelocytic leukemia zinc finger (Plzf) is a transcription repressor with multiple functions. Recent published results suggest a possible, important, role of Plzf in regulation of blood pressure, first via sodium reabsorption in kidney, an...

EB - Genetika a molekulární biologie

  • 2010 - 2013
    • •
  • 5 980 tis. Kč
    • •
  • 5 980 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 3 292