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11 654 (0,108s) •

Project

Mutants of tumor supressor protein p53 and regulation of thei DNA binding activity (KJB500040502)

and/or acrylamide gel. We will examine the possibility of activation p53 mutants to DNA binding p53 mutant binding properties to natural binding sequences in linear repair, cell...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 1 230 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • AV ČR
Project

Local DNA structures and their role in mutant p53 protein function in human tumours (GA22-21903S)

. Differences in mutant p53 binding to structured DNAs are poorly understood. We will systematically study binding of common mutant p53s to local DNA structures of various types localization to re...

Oncology

  • 2022 - 2024
    • •
  • 7 056 tis. Kč
    • •
  • 7 056 tis. Kč
    • •
  • GA ČR
Project

The role of p53 DNA structure-selective binding in brain cancer (GAP301/10/2370)

prognosis and dismal survival. Mutant p53 proteins acquire a -gain of function- activity. Attention will be aimed to molecular mechanism of how mutant p53 regulates invasive to non-B DNA structur...

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 1 757 tis. Kč
    • •
  • 1 757 tis. Kč
    • •
  • GA ČR
Project

Wild type and mutant p53 tumor suppressor protein. Intermolecular interactions, changes in conformation and new micro-methods of their analysis (IAA500040513)

of mutated p53, including DNA binding. Almost nothing is known about the mutant p53-specific binding of mutant p53 to scDNA will be investigated. In addition new chemicalThe tumor suppre...

CE - Biochemie

  • 2005 - 2008
    • •
  • 2 930 tis. Kč
    • •
  • 2 930 tis. Kč
    • •
  • AV ČR
Project

Interactions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy (IAA500040701)

biological activities. It was suggested that not only the wild type (wt) p53 sequence-specific DNA binding, but also ability of both wt and mutant (mut) p53 to recognize DNA binding, and (3) infl...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 824 tis. Kč
    • •
  • 4 824 tis. Kč
    • •
  • AV ČR
Project

Influence of DNA superhelicity on sequence specific and structure selective binding of the p53 protein (GP301/04/P025)

will test DNA binding properties of p53 mutants common in human cancers.Tumor suppressor protein p53 is one of the most important regulators of cell play crucial role in p53 protein function. DNA...

CE - Biochemie

  • 2004 - 2006
    • •
  • 720 tis. Kč
    • •
  • 720 tis. Kč
    • •
  • GA ČR
Project

Interactions of tumor suppressor proteins with DNA. Roles of DNA conformation and protein modifications (GA204/02/0734)

mutants (involving the p53 DNA-binding core and C-terminal domainsThe ability of tumor suppressor protein p53 to bind to specific DNA sequences and recombination. Loss of the p53 DNA binding<...

CE - Biochemie

  • 2002 - 2004
    • •
  • 4 448 tis. Kč
    • •
  • 3 042 tis. Kč
    • •
  • GA ČR
Project

The study of mechanisms regulating the activity of p53 protein and the possibilities of its latent forms activation in cancer cell (GA301/00/P094)

conformation. The activity of the p53 protein is regulated by its post-translational to cellularstress. Human p53 protein is a nuclear phosphoprotein. Its biochemical activity as a transcription factor. B...

EB - Genetika a molekulární biologie

  • 2000 - 2002
    • •
  • 730 tis. Kč
    • •
  • 627 tis. Kč
    • •
  • GA ČR
Project

Transcriptional activities of wild-type and mutant p53, decision between cell proliferation, cell cycle arrest and apoptosis (GAP301/10/1211)

of therapeutic agents used in cancer treatment to p53 binding properties by chromatinWe would like to perform complex study of the downstream regulated genes celldeath or cell cycle arrest. The major aim will consist of ch...

FD - Onkologie a hematologie

  • 2010 - 2012
    • •
  • 3 393 tis. Kč
    • •
  • 3 393 tis. Kč
    • •
  • GA ČR
Project

Function of the central domain of oncoprotein Mdm2 and its novel binding partners in the regulation of p53 tumour suppressor protein (GA301/09/1324)

Tumour suppressor p53 is an important regulator of cellular response to stress functionsare the N-terminal p53-binding domain and the C-terminal RING domain, where which mediates the binding of many negati...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 3 776 tis. Kč
    • •
  • 3 776 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 11 654