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1 291 (0,189s) •

Project

Comprehensive analysis of ovarian sex cord-stromal tumors (NU21-03-00238)

Ovarian sex cord-stromal tumors represent a heterogeneous category of tumors which account for 7 % of all ovarian tumors. The most common malignant tumor of this category is the adult granulosa cell tumor ...

Pathology

  • 2021 - 2024
    • •
  • 11 825 tis. Kč
    • •
  • 11 825 tis. Kč
    • •
  • MZ
Project

Molecular-biological and histopathological characteristics of tumor infiltrating lymphocytes as instrument of prediction of risk of early colorectal cancer recurrence (NT12025)

to the behavior of tumor infiltrating lymphocyte tissue between patients with colorectal...

FJ - Chirurgie včetně transplantologie

  • 2011 - 2014
    • •
  • 5 261 tis. Kč
    • •
  • 5 261 tis. Kč
    • •
  • MZ
Project

The use of surface glycosylation in the immune recognition and elimination of tumors (GA204/06/0771)

carcinoma and melanoma in vivo relate to the changes in surface tumor glycosylation glycosylation of the cell lines relevant to the above tumor models related to different malignant phenotypes and sensitivity for killer lymphoc...

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 2 940 tis. Kč
    • •
  • 2 940 tis. Kč
    • •
  • GA ČR
Project

Predictive factors of pathologic response to neoadjuvant chemotherapy in patients with HER-2 positive or triple negative breast carcinoma (NT13564)

centers difference in tumor infiltrating lymphocytes in patients with different tumor and the presence of tumor infiltrating lymphocytes will be evaluated together with tumor response was observe...

FD - Onkologie a hematologie

  • 2012 - 2015
    • •
  • 9 695 tis. Kč
    • •
  • 9 695 tis. Kč
    • •
  • MZ
Project

The ability of dendritic cells to stimulate the tumor specific immune response in patients with lymphoid malignancies (NR8092)

The ability of intranodally injected dendritic cells, pulsed with tetanus toxm toxoid or apoptotic tumor cells will be studied in 20-40 patients with chronic laboratory experiments will evaluate the chemokine production by tumor cel...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 1 660 tis. Kč
    • •
  • 1 513 tis. Kč
    • •
  • MZ
Project

Generation of dendritic cells in vitro, their characteristics, antigen presenting capacity and potential use in the immunotherapy of minimal residual disease in (NI5669)

Monocyte-derived dendritic cells cultivated in vitro will be pulsed with tumor antigens and cocultivated with autologous lymphocytes in vitro to gain efficient cytotoxic cells directed against tumor cells. The project is fo...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1999 - 2001
    • •
  • 1 362 tis. Kč
    • •
  • 1 362 tis. Kč
    • •
  • MZ
Project

Immunotherapy Using Different Tumor Antigens in The Treatment of Multiple Myeloma (NR8945)

anti-tumor T-lymphocytes at patients with multiple myeloma. Clinical part cells, myeloma mRNA or peptides derived from tumor associated proteins will be used as tumor antigens. This approach will lead to the choic...

FD - Onkologie a hematologie

  • 2006 - 2009
    • •
  • 6 929 tis. Kč
    • •
  • 6 587 tis. Kč
    • •
  • MZ
Project

Glycomic and proteomic analysis of the molecular mechanisms of elimination of clinically relevant tumors by killer cells of the immune system (GA303/09/0477)

the recognition and elimination of tumor cells by the killer cells of the immune system. Moreover, the relation of tumor surface glycosylation to binding of cytotoxic cells, their activation, and apoptosis of both killer cells and ...

CE - Biochemie

  • 2009 - 2013
    • •
  • 4 259 tis. Kč
    • •
  • 4 259 tis. Kč
    • •
  • GA ČR
Project

Correlation of immunotherapeutic molecular targets with gut microbiome in NSCLC patients (NV19-03-00069)

During the recent years, cancer immunotherapy has been rediscovered and in some cases of solid and haematological tumours also successfully implemented into the therapeutic strategy. Tumour infiltrating T lymphocytes exists in different func...

Oncology

  • 2019 - 2022
    • •
  • 14 064 tis. Kč
    • •
  • 14 064 tis. Kč
    • •
  • MZ
Project

The prognostic predictive markers in penile carcinoma a molecular and morphological study. (NU21J-03-00019)

to a metastatic disease and death of affected persons, whereas there is only a localized tumor potential from less aggressive tumors. Identification of such markers may lead not been fully clarified. For example, infection by human...

Pathology

  • 2021 - 2024
    • •
  • 6 978 tis. Kč
    • •
  • 6 978 tis. Kč
    • •
  • MZ
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