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14 724 (0,148s) •

Project

Applications of chemical structural probes and electroanalytical methods in DNA damage detection. Development of DNA sensors. (KJB4004302)

In this project we propose to employ chemical probing of DNA structure, in connection with biochemical methods and electrochemical detection, in analysis of DNA damage. Monitoring of DNA-damaging ...

CG - Elektrochemie

  • 2003 - 2005
    • •
  • 2 052 tis. Kč
    • •
  • 1 212 tis. Kč
    • •
  • AV ČR
Project

Local DNA structures ,their chemical reactivity and relations to genetic diseases and cancer (GA204/96/1680)

This laboratory proposed earlier single-strand selective chemical probes of the DNA structure based on osmium tetroxide complexes with nitrogen ligand (Os,L analysis based on Os,L will be proposed. Chemical

CE - Biochemie

  • 1996 - 1998
    • •
  • 3 707 tis. Kč
    • •
  • 2 871 tis. Kč
    • •
  • GA ČR
Project

Analysis of DNA structure and interactions using electrochemical techniques and chemical probes. Novel techniques and sensors for DNA damage detection (GA203/07/1195)

Development and application of electrochemical methods and biosensors in studies of nucleic acids structure and interactions and/or in detection of DNA new methods of detection of DNA damage, its chemical modificat...

CG - Elektrochemie

  • 2007 - 2009
    • •
  • 4 192 tis. Kč
    • •
  • 4 192 tis. Kč
    • •
  • GA ČR
Project

Electrochemical and optical analysis of biomacromolecules at the microelectrodes modified by a electroactive material nanolayer (KAN200040651)

of biomacromolecules in relation to their structure at the electrical charged surface of a new electrode materials, whose physical-chemical properties are determined by surfacetreatment and/or structure in nanoscale dimens...

BO - Biofyzika

  • 2006 - 2010
    • •
  • 7 259 tis. Kč
    • •
  • 6 529 tis. Kč
    • •
  • AV ČR
Project

Translesion DNA synthesis across lesions induced by agents of biological significance. An insight into energetics, kinetics and mechanism (GA17-09436S)

The biological effects of DNA-damaging physical and chemical agents are associated with their ability to affect DNA replication. The main objective of DNA due to its damage by DNA-damaging agents is an imp...

BO - Biofyzika

  • 2017 - 2019
    • •
  • 5 627 tis. Kč
    • •
  • 5 006 tis. Kč
    • •
  • GA ČR
Project

Recognizing DNA damage by Tumor Suppressor Proteins. Effects of Anti - Cancer Drugs. (NC7574)

microbalance and chemical probing of DNA, proteins and their complexes combined of protein p53 (and its homologues) with damaged DNA will be studied. Our efforts of individual protein domains in DNA damag...

FC - Pneumologie

  • 2003 - 2005
    • •
  • 2 921 tis. Kč
    • •
  • 2 004 tis. Kč
    • •
  • MZ
Project

Development of painting DNA probes by laser microdissection of bovine chromosomes and their use in the diagnostics of chromosomal aberrations (GA523/01/0291)

The project is focused on the development of painting DNA probes and gain of new information on structural chromosomal abnormalities in farm animals by means of FISH. Laser microdissection technique will be used for the pre...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 4 279 tis. Kč
    • •
  • 3 462 tis. Kč
    • •
  • GA ČR
Project

Interactions of mutant p53 with genomic DNA in vitro and in vivo (1K04119)

for the detection of DNA-protein interactions, computer analysis of DNA structure, chemical and enzymatic probes, electrochemical analysis of DNA and proteins and techniques mutp53 DNA b...

EB - Genetika a molekulární biologie

  • 2004 - 2007
    • •
  • 2 672 tis. Kč
    • •
  • 2 420 tis. Kč
    • •
  • MŠMT
Project

Electrochemical tools for detection of point mutations and polymorphisms in DNA (GP203/08/P598)

behaviour and use them as signalling probes in DNA hybridization. OsO4 complexes will be used as chemical probes for unpaired and mispaired bases in DNA heteroduplexes. This principle will be utilized in ...

CG - Elektrochemie

  • 2008 - 2010
    • •
  • 1 404 tis. Kč
    • •
  • 1 404 tis. Kč
    • •
  • GA ČR
Project

DNA probe test for diagnosis of STD, comparsion of Micro-probe DNA test and culture for the detection of Candida sp.in urogenetal specimens. (IZ3161)

9F - 9

  • 1995 - 1996
    • •
  • 114 tis. Kč
    • •
  • 114 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 14 724