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546 (0,138s) •

Project

Study of integrase and pre-integration complex of monkey retrovirus (GP203/05/P557)

replication. Mason-Pfizer Monkey Virus (M-PMV), a representative of ß-retrovirus family the process ofintegration nor the reverse transcriptase and the integrase (IN) of M-PMV have been characterized yet. Here we ...

CE - Biochemie

  • 2005 - 2007
    • •
  • 1 140 tis. Kč
    • •
  • 1 140 tis. Kč
    • •
  • GA ČR
Project

Structural and functional study of matrix protein and proteinaseof monkey immunosuppressive retrovirus (GA203/97/0416)

Mason-Pfizer monkey virus (M-PMV) induces an AIDS like syndrome in non-human primates. M-PMV fas a prototype of the D-type retroviruses provides an advantageous in M-PMV matrix protein (MA) can al...

CE - Biochemie

  • 1997 - 1999
    • •
  • 2 843 tis. Kč
    • •
  • 1 809 tis. Kč
    • •
  • GA ČR
Project

The Study of the Conformation of Structural Proteins of Monkey Retrovirus M-PMV Proteolytic Cleavage and Its Inhibition. (GA203/94/1323)

CE - Biochemie

  • 1994 - 1996
    • •
  • 2 188 tis. Kč
    • •
  • 2 441 tis. Kč
    • •
  • GA ČR
Project

Structure of retroviral particle and intracellular transport of its components. (LH12011)

Vectors expressing fluorescently tagged envelope and structural protein mutants of M-PMV altering assembly, transport or capsid release will be prepared. ?Live imaging? established in US laboratory will be employed for analysis of p...

EE - Mikrobiologie, virologie

  • 2012 - 2015
    • •
  • 1 990 tis. Kč
    • •
  • 1 990 tis. Kč
    • •
  • MŠMT
Project

Biological and structural studies of Mason-Pfizer monkey virus protease (GA203/00/1241)

. Recently we have shown that unlike other retroviral proteases the M-PMV PR exists is a continuationof the study of behavior and qualities of the M-PMV P that has been carrying out more information about a three-d...

CE - Biochemie

  • 2000 - 2002
    • •
  • 3 657 tis. Kč
    • •
  • 2 798 tis. Kč
    • •
  • GA ČR
Project

Structure and assembly of retroviral proteins - specific domains responsible for these processes (GA203/00/1005)

Mason-Pfizer monkey virus (M-PMV) can be assembled in vitro and we have solved the solution structure of its matrix protein (MA). The suitability of M-PMV as a model for the proposed study is justified both by the...

CE - Biochemie

  • 2000 - 2002
    • •
  • 2 415 tis. Kč
    • •
  • 2 115 tis. Kč
    • •
  • GA ČR
Project

The effect of mutations and morphogenetic differences in matrix proteins on assembly and transport of retroviral capsids (GA203/98/P151)

Matrix protein (MA) of Mason-Pfizer monkey virus (M-PMV), which is the prototype of the type D retroviruses, plays a critical role in retroviral replication cycle. A mutant of MA, which changes morphogenetic type D to that of C cons...

CE - Biochemie

  • 1998 - 2000
    • •
  • 822 tis. Kč
    • •
  • 703 tis. Kč
    • •
  • GA ČR
Project

Structural study of protein domains of monkey retrovirus (IAA4055304)

Temporal and spatial separation of assembly of immature capsid particles from their release makes Mason-Pfizer monkey virus (M-PMV), inducing an AIDS like syndrom in non of the scaffolding protein p12 and the 13 kDa form of M

CE - Biochemie

  • 2003 - 2007
    • •
  • 11 354 tis. Kč
    • •
  • 4 282 tis. Kč
    • •
  • AV ČR
Project

Interaction and structural changes of retroviral MA domain of Gag due to plasma membrane binding and implications for the virus maturation (GA22-19250S)

of the Gag during maturation of HIV-1, Mason-Pfizer monkey (M-PMV) and Rous sarcoma virus plan to determine the mechanisms modulating C-terminal cleavage of MA in M-PMV......

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 7 758 tis. Kč
    • •
  • 7 199 tis. Kč
    • •
  • GA ČR
Project

Study of structure, function and inhibition of retroviral integrase and proteinase (IAA4055904)

of integration, we will express the integrase (IN) and the mutants of IN of virus M-PMV and the results will be compared with these obtained for M-PMV PR.......

CE - Biochemie

  • 1999 - 2001
    • •
  • 8 099 tis. Kč
    • •
  • 1 959 tis. Kč
    • •
  • AV ČR
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