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1 213 (0,087s) •

Project

Molecular mechanisms of non-canonical Wnt signaling in leukemia (GAP301/11/0747)

Wnts, a family of glycoproteins, signal through a variety of signaling pathways of non-canonical Wnt signalling (Wnt/PCP pathway) in context of B-Cell Chronic LymphocyticLeukaemia (CLL). Functional studies...

FD - Onkologie a hematologie

  • 2011 - 2014
    • •
  • 5 360 tis. Kč
    • •
  • 5 360 tis. Kč
    • •
  • GA ČR
Project

The role of beta-arrestin in achieving Wnt-signaling specificity (GC204/09/J030)

-canonical Wnt-pathways. A number of new variations of Wnt-signaling, especially in noncanonical pathways has been described lately, most of them involving Dsh or trimeric G of the individual branches of Wnt

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 3 888 tis. Kč
    • •
  • 3 888 tis. Kč
    • •
  • GA ČR
Project

Molecular cloning and functional characterization of the Wnt signaling pathway components in man (IAA5052905)

of the opithelial cells, hasbeen observed in human colon carcinomas upon the aberrant Wnt activation. These data imply a regulatory role of the Wnt pathway in the intestinalWnt proteins are secreted signaling mole...

EB - Genetika a molekulární biologie

  • 1999 - 2002
    • •
  • 2 936 tis. Kč
    • •
  • 1 676 tis. Kč
    • •
  • AV ČR
Project

The role of Wnt/beta-catenin signaling during neurogenesis. (GA17-05466S)

Wnt signaling plays an essential role in the development of mammalian CNS. We will investigate the impact of the canonical Wnt pathway both on neuronal/glial differentiation or the Wnt inhibitor Dkk1. Furthermore, ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2021
    • •
  • 5 720 tis. Kč
    • •
  • 5 556 tis. Kč
    • •
  • GA ČR
Project

Characterization of early stages of intestinal tumorigenesis induced by non-physiological activation of Wnt signaling (GA20-31322S)

The Wnt signaling pathway regulates a number of biological processes during embryonic development and in adult tissues. Dysfunction of Wnt signaling initiates of Wnt pathway inhibitor, tumor suppressor APC...

Cell biology

  • 2020 - 2022
    • •
  • 8 985 tis. Kč
    • •
  • 8 985 tis. Kč
    • •
  • GA ČR
Project

Tumor suppressors in the Wnt signaling pathway (GA204/07/1567)

Wnt signaling controls embryonic development and the aberrant activation of the Wnt pathway leads to cancer. In canonical signaling beta-catenin acts with the TCF of the Wnt pathway. HIC1 encodes a zinc-fi...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 433 tis. Kč
    • •
  • 4 433 tis. Kč
    • •
  • GA ČR
Project

Dynamics of proteins interacting with Dishevelled and their importance for Wnt signalling (GA204/09/0498)

Mutations in the Wnt signalling pathway cause several human diseases including (Dvl) ? a key component of the Wnt signalling pathway. We plan to describe with respect (i) to the Wnt pathway activa...

CE - Biochemie

  • 2009 - 2013
    • •
  • 6 895 tis. Kč
    • •
  • 6 895 tis. Kč
    • •
  • GA ČR
Project

Posttranslational modification of Dishevelled (KJB501630801)

Wnts are secreted factors and regulators of embryonic development, disease and regeneration. Mutations in the Wnt pathway are crucial in pathogenesis of many diseases, including cancer. Wnts bind Frizzled family of...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 1 290 tis. Kč
    • •
  • 1 290 tis. Kč
    • •
  • AV ČR
Project

The role of non-canonical Wnt signaling in molecular pathogenesis of chronic lymphocytic leukemia (NT11217)

The proposed project attempts to clarify the role of non-canonical Wnt pathway in diagnosis, prognosis and in molecular pathogenesis of chronic lymphocytic leukemia (CLL-canonical Wnt pathway at transcript (RT-PCR)...

FD - Onkologie a hematologie

  • 2010 - 2014
    • •
  • 9 860 tis. Kč
    • •
  • 9 860 tis. Kč
    • •
  • MZ
Project

Analysis of WNT/PCP pathway for better management of chronic lymphocytic leukemia (NV15-29793A)

of the crucial molecular pathways associated with pathogenesis of CLL is Wnt/PCP signaling pathway. Our results showed that the key components of Wnt/PCP pathway are upregulated and disease biology. These...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 9 937 tis. Kč
    • •
  • 9 937 tis. Kč
    • •
  • MZ
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