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5 344 (0,153s) •

Project

Interactions defining physiological functions of Microtubule Associated Protein 2c at atomic resolution (GA20-12669S)

Microtubule associated protein 2c (MAP2c) is a key factor regulating microtubule dynamics in developing brain neurons, and an example of an intrinsically disordered proteins with an important phys...

Biochemistry and molecular biology

  • 2020 - 2022
    • •
  • 6 007 tis. Kč
    • •
  • 6 007 tis. Kč
    • •
  • GA ČR
Project

Atomic-resolution characterization of microtubule associated protein 2c (MAP2c) and of modifications regulating its function (GA15-14974S)

studies of large IDPs possible. We propose to apply the methodology to microtubule associated protein 2c (MAP2c), a 49 kDa IDP involved in an early step of neuriteIntrinsically disordered proteins (IDPs) ...

BO - Biofyzika

  • 2015 - 2018
    • •
  • 6 460 tis. Kč
    • •
  • 6 460 tis. Kč
    • •
  • GA ČR
Project

Study of domain interactions of intrinsically disordered protein MAP2c (Microtubule-Associated Protein 2c) with its binding partners via computational methods and nuclear magnetic resonance (LTC17078)

The main focus of this project is MAP2c (Microtubule-Associated Protein 2c) protein, an IDP regulating structure and dynamics (polymerization and degradation) of microtubules (MTs) which is essent...

CE - Biochemie

  • 2017 - 2019
    • •
  • 1 425 tis. Kč
    • •
  • 1 425 tis. Kč
    • •
  • MŠMT
Project

Characterization of intrinsically disordered proteins (GF20-05789L)

are the microtubule associated protein 2c (MAP2c) and its homologous tau protein.Intrinsically disordered proteins (IDPs) are biopolymers interesting both from biophysical and physiological point...

Biophysics

  • 2020 - 2022
    • •
  • 8 686 tis. Kč
    • •
  • 8 686 tis. Kč
    • •
  • GA ČR
Project

Microtubule-binding function of plant HSP90/82 protein (ME10111)

The goal of the project is to define the role of HSP90/82 associated with its microtubule- and membrane-binding functions in plant cells. Further, using unique biochemical methods, new proteins binding both microtubules...

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 1 650 tis. Kč
    • •
  • 1 650 tis. Kč
    • •
  • MŠMT
Project

Regulation of microtubule organization by ufmylation ligase complex and C53 signaling protein (GA19-20716S)

that modulates microtubule nucleation and stabilizes C53. ER-mitochondria-associatedWhile a role of γ-tubulin complexes in microtubule nucleation is well established, functions of membrane-associated γ-tubulins ar...

Cell biology

  • 2019 - 2021
    • •
  • 7 692 tis. Kč
    • •
  • 7 203 tis. Kč
    • •
  • GA ČR
Project

Molecular analysis of structure and function of microtubule-associated protein syncolin (IAA5052701)

relationship of syncolin, new microtubule-associated protein (NAPs) in marginal band and characterization of tissuedistribution of this protein. Syncolin expression in early stages of embryonic development and its...

EB - Genetika a molekulární biologie

  • 1997 - 1999
    • •
  • 2 344 tis. Kč
    • •
  • 905 tis. Kč
    • •
  • AV ČR
Project

Translating microtubule envelope sectioning into cytoskeletal structure and function (GA20-04068S)

Modulating the accessibility of microtubules for associated proteins expect other microtubule-associated IDPs to collectively form a continuous envelope for other proteins, including microtubu...

Biophysics

  • 2020 - 2022
    • •
  • 7 804 tis. Kč
    • •
  • 7 804 tis. Kč
    • •
  • GA ČR
Project

Functional analysis of the Maol protein of the yeast S. cerevisiae (GA204/98/P256)

microtubules and microtubule-associated proteins in yeast morphogenesis", which was aimed to the identification of microtubule-associated proteins (MAPs) in yeast and the evaluation 210 ...

EA - Morfologické obory a cytologie

  • 1998 - 1999
    • •
  • 360 tis. Kč
    • •
  • 335 tis. Kč
    • •
  • GA ČR
Project

Microtubule-binding function of plant HSP82/90 (MEB100904)

Trough different and completely independent approaches, both partners labs have identified members of the platn heat-shock protein 90/82 (HSP 90/82) family as microtubule-binding protein in two different plant species, toba...

EA - Morfologické obory a cytologie

  • 2009 - 2009
    • •
  • 48 tis. Kč
    • •
  • 48 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 5 344