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9 (0,082s) •

Project

Phototoxic effects of xenobiotics - an in vitro test system (IZ3985)

The aim of the Project is to develop an alternative in vitro method for xenobiotics phototoxicity assessment to avoid testing on animals, using stabilized cell line tissue culture and detection of effect at cellular and subcellular level by ...

FM - Hygiena

  • 1997 - 1999
    • •
  • 2 157 tis. Kč
    • •
  • 1 473 tis. Kč
    • •
  • MZ
Project

Modulation of human skin cell responses to UVA radiation by silymarin components (GA15-10897S)

in cosmetic preparations, their photostability and phototoxicity on human skin cells have is to evaluate the bioavailability, photostability, phototoxicity and UV-modulated......

DN - Vliv životního prostředí na zdraví

  • 2015 - 2017
    • •
  • 5 469 tis. Kč
    • •
  • 5 469 tis. Kč
    • •
  • GA ČR
Project

Photodynamic sensitizers bound to cyclodextrin carriers (GA203/02/1483)

The main aim of this project is to determine how the presence of cyclodextrins (CD) carriers affects the physical and photophysical properties and phototoxicity of selected photodynamic sensitizers. We plan to investigate the stoichiometries...

CA - Anorganická chemie

  • 2002 - 2004
    • •
  • 3 391 tis. Kč
    • •
  • 2 383 tis. Kč
    • •
  • GA ČR
Project

Health risks of local skin toxicity determined by alternative toxicological methods in vitro (NS9648)

/corrosion, phototoxicity hazard and skin absorption/ penetration as a prerequisite...

FM - Hygiena

  • 2008 - 2011
    • •
  • 5 152 tis. Kč
    • •
  • 5 152 tis. Kč
    • •
  • MZ
Project

Water nanodispersion for functional surface treatment (TA01010613)

Suggestion of TiO2 nanodispersions for safety surface treatment. There will be suggested non-toxic UV filters, which were used for skin penetration assessment and for effective photoprotective emulsion preparation. This emulsion will be constituted t...

CD - Makromolekulární chemie

  • 2011 - 2014
    • •
  • 25 757 tis. Kč
    • •
  • 20 053 tis. Kč
    • •
  • TA ČR
Project

Photoprotective effects of natural plant phenolics in vitro and in vivo (GP303/07/P314)

The aim of the project is to establish in vitro model for monitoring UVB phototoxicity on human keratinocytes and in vivo model for monitoring UVA and UVB skin photodamage on SKH 1-HR hairless mice, and then to study effects of selected natu...

CE - Biochemie

  • 2007 - 2009
    • •
  • 1 157 tis. Kč
    • •
  • 1 157 tis. Kč
    • •
  • GA ČR
Project

Identification and localization of protein complexes involved in the regulation of chlorophyll biosynthesis (GAP501/10/1000)

Chlorophyll (Chl) and heme are produced via a common branched pathway that has to be tightly regulated as many tetrapyrroles are phototoxic and the demand for heme or Chl varies according to development or light conditions. To understand how...

ED - Fyziologie

  • 2010 - 2013
    • •
  • 4 049 tis. Kč
    • •
  • 4 049 tis. Kč
    • •
  • GA ČR
Project

Regulation of chlorophyll trafficking in the cyanobacterial cell (GA17-08755S)

Photosystems (PSI and PSII) are membrane-embedded assemblages of proteins, chlorophylls (Chls) and other cofactors. The biogenesis of PSI and PSII is a strictly regulated task as the core subunits bind many Chls and, due to the phototoxic na...

CE - Biochemie

  • 2017 - 2019
    • •
  • 5 131 tis. Kč
    • •
  • 5 089 tis. Kč
    • •
  • GA ČR
Project

Cluster-based nanoparticles for theranostics (8J20FR008)

, toxicity, phototoxicity, and radiotoxicity of nanoparticles will be tested using...

Inorganic and nuclear chemistry

  • 2020 - 2022
    • •
  • 146 tis. Kč
    • •
  • 146 tis. Kč
    • •
  • MŠMT
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