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2 246 (0,128s) •

Project

Experimental therapy and receptor mechanism of benzodiazepine dependence studied by PCR in situ. (IZ3612)

FL - Psychiatrie, sexuologie

  • 1996 - 1998
    • •
  • 1 457 tis. Kč
    • •
  • 1 457 tis. Kč
    • •
  • MZ
Project

Molecular aspects of diagnostics and therapy of spinal muscular atrophy (1A8608)

splicing. Transcription and splicing of the SMN1 gene results in full-length mRNA 7. Compounds affecting SMN mRNA splicing towards exon 7 inclusion could be used in therapy. The project expands SMA diagnostics by detection...

FH - Neurologie, neurochirurgie, neurovědy

  • 2005 - 2008
    • •
  • 4 414 tis. Kč
    • •
  • 4 335 tis. Kč
    • •
  • MZ
Project

A humanized organoid-based platform for stroke modelling and mRNA-based therapeutic intervention (GA24-11364S)

and mRNA-based therapy, which will extend the current spectrum of stroke models in pre technologies, disease modeling using brain organoids and mRNA-based therapeutic stroke and modulate them by mRNA-based interve...

Neurosciences (including psychophysiology)

  • 2024 - 2026
    • •
  • 10 693 tis. Kč
    • •
  • 10 693 tis. Kč
    • •
  • GA ČR
Project

Transplantation therapy of diabetes with insulin-producing cells derived by reprogramming of non-endocrine pancreatic cells (NV15-25924A)

reprogramming that is based on the application of synthetic modified mRNA could solve all these issues. Therefore we propose to use synthetic modified mRNAs encoding key......

FJ - Chirurgie včetně transplantologie

  • 2015 - 2018
    • •
  • 6 146 tis. Kč
    • •
  • 6 146 tis. Kč
    • •
  • MZ
Project

Clinical significance of minimal residual disease in patients with operable lung cancer (NS10285)

and systemic therapy using specific markers (CEA, c-met messenger RNA, EGFRand VEGFR mRNA, mRNA telomerase, CC-20). Evaluation of possible utilisation of MRD in tailoring and monitoring response to local and systemic t...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 4 989 tis. Kč
    • •
  • 4 823 tis. Kč
    • •
  • MZ
Project

Integration of novel RNA-nanotherapeutics in patient-derived breast cancer organoids (NU23J-08-00035)

RNA-based therapy is revolutionizing the healthcare strategy worldwide. The flexible design of RNA molecules combined with the scalability and tunability of lipid, thus paving the way to personalized therapies based on the patient’s...

Biochemistry and molecular biology

  • 2023 - 2026
    • •
  • 6 894 tis. Kč
    • •
  • 6 894 tis. Kč
    • •
  • MZ
Project

Small Compounds Affecting RNA Elements (SCARE) in mRNA 3'UTRs (GA22-20110S)

RNA is an attractive drug target with tremendous potential for future therapies is non-protein-coding including 3’UTRs of mRNAs with important regulatory functions. Therefore, targeting these proteins via their mRNA 3’UTR r...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 11 747 tis. Kč
    • •
  • 11 456 tis. Kč
    • •
  • GA ČR
Project

Monitoring of MxA mRNA Expression as a Marker of Rresponse to Interferon ß Therapy in Patients with Multiple Sclerosis. (NT12385)

IFNß is the first line treatement of MS therapy. Following IFNß administration lymphocytes produce MxA (Myxovirus Resistance Protein A) protein. MxA mRNA assay is considered the marker of bioactivity of IFNß. Nonresponsivness to IFN...

FH - Neurologie, neurochirurgie, neurovědy

  • 2011 - 2015
    • •
  • 6 728 tis. Kč
    • •
  • 6 728 tis. Kč
    • •
  • MZ
Project

Introduction of DNA microarray methodology and its application in antitumor therapy (1K04017)

and also for potential gene therapy. DNA microarray technology was established for determination of mRNA expression of thousands of genes simultaneously. This methodology anticancer therapy. Key differentially expressed ge...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 7 428 tis. Kč
    • •
  • 3 177 tis. Kč
    • •
  • MŠMT
Project

Prevalence a biological consequencies of Human Herpesvirus 6 (HHV6) chromosomal integration in paediatric and adult patients treated with malignant disease (NS9907)

Prevalence of HHV6 chromosomal integration in severely immunosupressed patients endangered by highest risk of misinterpretation of HHV6 PCR positive result and side effects of subsequent virostatic therapy. Clarify of so far unknown serologi...

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 3 147 tis. Kč
    • •
  • 3 147 tis. Kč
    • •
  • MZ
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