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28 (0,137s) •

Project

Prediction of termination of pregnancy in women with serious hepatopathies (NT12211)

We will build a prediction model for estimation of optimal pregnancy termination in women with intrahepatic cholestasis (ICP). For the construction of this model the steroid metabolome (about 100 steroids and related substances), so...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2011 - 2015
    • •
  • 7 549 tis. Kč
    • •
  • 7 549 tis. Kč
    • •
  • MZ
Project

Ursodeoxycholic acid and S - adenyl methion in treatment intrahepatic cholestasis of pregnancy.Biochemical and hematological aspects of the disease menacing mother and fetus. (NH7376)

The project shoud assess the impact of administration of ursodeoxycholic acid and S-adenyl methionin on pregnant with ICP from the viewpoint of suppression of clinical and lab signs of the disorder and safety continunance of pregnancy for fetus. The ...

FK - Gynekologie a porodnictví

  • 2003 - 2005
    • •
  • 975 tis. Kč
    • •
  • 946 tis. Kč
    • •
  • MZ
Project

Molecular basis and mechanisms of familial intrahepatic cholestasis (NV18-06-00032)

Between 2002- 2017 we analyzed gDNA of 123 unrelated index patiens with suspect progressive or recurrent intrahepatic cholestasis (PFIC or BRIC). Mutation analysis of ATP8B1, ABCB11, ABCB4 and TJP2 was run in 82 patiens with low GGT...

General and internal medicine

  • 2018 - 2022
    • •
  • 8 630 tis. Kč
    • •
  • 8 526 tis. Kč
    • •
  • MZ
Project

Perspective application of xenosensor nuclear receptors ligands in therapy of cholestatic liver diseases (GA22-05167S)

, and to protect BA-induced liver injury in cholestasis. In the project, we will elucidate (i) if prototype Car agonist TCPOBOP has a therapeutic effect in models of intrahepatic cholestasis in pregnancy (ICP) and xenobioti...

Pharmacology and pharmacy

  • 2022 - 2024
    • •
  • 12 904 tis. Kč
    • •
  • 12 856 tis. Kč
    • •
  • GA ČR
Project

Profiling of neurosteroid conjugates and other acidic metabolites in body fluids and their perspective in clinical diagnostics (NT11513)

of congenital adrenal hyperplasia, postpartum mental disorders and intrahepatic cholestasis...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2010 - 2014
    • •
  • 8 975 tis. Kč
    • •
  • 8 975 tis. Kč
    • •
  • MZ
Project

Role of the Heme Oxygenase in the Pathogenesis of Cholestasis (NT11327)

incholestasis. Cholestasis is a complication of many liver diseases leading to increased contribute to the regulation of HO during cholestasis. Performing in vivo studies and the adaptive mechanisms in cholestasis. In the ...

FE - Ostatní obory vnitřního lékařství

  • 2010 - 2013
    • •
  • 5 131 tis. Kč
    • •
  • 5 131 tis. Kč
    • •
  • MZ
Project

The role of heme catabolic pathway in in the pathogenesis of cholestasis (NR9366)

The proposed grant project is focused on the role of HO and its metabolic products, bilirubin and carbon monoxide (CO) on the maintenance of bile flow and sinusoidal tone in the liver tissue, in particular its role in the pathogenesis of cholesta...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2010
    • •
  • 4 406 tis. Kč
    • •
  • 4 406 tis. Kč
    • •
  • MZ
Project

Changes of glycosignalig in canalicular membrane of hepatocytes in the pathogenesis of cholestasis and cholelithiasis (NB6758)

Concentration of (glyco)sphingolipids and signal proteins in the basic principle by which these domains perform their function. The sphingolipid and protein compositions of domains under physiological conditions and in cholestasis will studi...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 2 845 tis. Kč
    • •
  • 2 810 tis. Kč
    • •
  • MZ
Project

ROLE OF CANALICULAR MEMBRANE TRANSPORTERS IN CHOLESTATIC LIVER DISEASES (NM7510)

A search for mutations in genes encoding canalicular membrane transporters of bile salts, phospholipids and bile pigments will be performed in patients with chronic inrahepatic cholestasis and Rotor syndrome. In addition to that a group of f...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
    • •
  • 2 858 tis. Kč
    • •
  • 2 845 tis. Kč
    • •
  • MZ
Project

Can Statins Attenuate a development of cholestatic liver disease? (NS9739)

Extrahepatic cholestasis will be induced by the method of common bile duct ligation. The potential effect of fluvastatin attenuating the development of cholestatic liver injury will be evaluated by the mesurements of the markers of liver inj...

FJ - Chirurgie včetně transplantologie

  • 2008 - 2010
    • •
  • 2 273 tis. Kč
    • •
  • 2 273 tis. Kč
    • •
  • MZ
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