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1 057 (0,114s) •

Project

Mitoribosome in Trypanosoma brucei biogenesis and unique traits of a divergent protein synthesis machine (GJ20-04150Y)

mitochondrial membrane, how the highly hydrophobic translation products are co-translationally inserted into the membrane, and why the polypeptide exit tunnel branches features of mitochondrial translation

Biochemistry and molecular biology

  • 2020 - 2023
    • •
  • 6 855 tis. Kč
    • •
  • 6 855 tis. Kč
    • •
  • GA ČR
Project

Synthetic lethal interactions of the mitochondrial integrated stress response in MYC-driven tumors (GA25-16629S)

, the mitochondrially activated ISR (mitoISR) restores mitochondrial homeostasis or triggers to the inhibition of mitochondrial gene expression machinery remain poorly understood. Building will develop novel inducible MYC/M...

Cell biology

  • 2025 - 2027
    • •
  • 9 694 tis. Kč
    • •
  • 9 694 tis. Kč
    • •
  • GA ČR
Project

The evolution of mitochondrial biogenesis. (GAP305/10/0651)

of molecular machines in their membranes, by which they transport proteins translated on the cytosolic ribosomes. Across the eukaryotic diversity mitochondrial proteoms can range mitochondrial proteins. By studying these m...

EB - Genetika a molekulární biologie

  • 2010 - 2014
    • •
  • 4 789 tis. Kč
    • •
  • 4 789 tis. Kč
    • •
  • GA ČR
Project

Molecular regulations of mitochondrial ATP-synthase and their impact on insulin secretion from pancreatic beta cells (GJ15-02022Y)

The mitochondrial ATPsynthase has a cardinal role in glucose-induced insulin secretion (GSIS) by pancreatic β-cells. Consequently, regulatory mechanisms of mt ATPsynthase activity such as endogenous regulatory protein IF1, or post-transl...

CE - Biochemie

  • 2015 - 2017
    • •
  • 5 638 tis. Kč
    • •
  • 5 638 tis. Kč
    • •
  • GA ČR
Project

Organellar translation as an evolutionary playground (GA23-05764S)

Mitochondria and plastids possess a translation apparatus inherited from in the structural and functional details of organellar translation across the eukaryote selected topics of organellar translation, each documenting a ...

Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

  • 2023 - 2025
    • •
  • 9 520 tis. Kč
    • •
  • 9 520 tis. Kč
    • •
  • GA ČR
Project

Role of receptor tyrosine kinase Her2 in mitochondria (GA16-12719S)

obvious that mitochondrial Her2 also increases expression of mitochondrial respiratory on bioenergetics, the ability of Her2 to phosphorylate mitochondrial proteins and the manner of the receptor tyrosine kinase in mitocho...

EB - Genetika a molekulární biologie

  • 2016 - 2018
    • •
  • 6 654 tis. Kč
    • •
  • 6 543 tis. Kč
    • •
  • GA ČR
Project

The role of antioxidants and mitochondrial phospholipase iPLA2γ in the protection against cerebral ischemia (LTAUSA17174)

Aim 1. To determine hypoxia-induced changes in mitochondrial network, superoxide formation, and NADP/NADH ratio in the absence or presence of exogenous antioxidants SkQ1 and SkQR1 Aim 2. To determine hypoxia-induced changes in mitochondr...

ED - Fyziologie

  • 2017 - 2021
    • •
  • 8 144 tis. Kč
    • •
  • 8 144 tis. Kč
    • •
  • MŠMT
Project

Mechanisms of Neuroprotective Action of FTO Inhibitors in Brain Mitochondrial Impairment and Alzheimer’s Disease (GA25-17745S)

dysregulation, particularly mitochondrial dysfunction, as a key pathological hallmark interplay between the FTO-m6A pathway and mitochondrial dynamics in neurons of sporadic AD. Overall, this project has the potential to accelerate...

Neurosciences (including psychophysiology)

  • 2025 - 2027
    • •
  • 8 139 tis. Kč
    • •
  • 8 139 tis. Kč
    • •
  • GA ČR
Project

Mitochondrial optic neuropathies a complex genetic and metabolomic analysis to characterize molecular bases and to identify novel biomarkers (NU22-07-00614)

Mitochondrial diseases are a heterogeneous group of genetic rare disorders spectrum of mitochondrial disorders. Leber hereditary optic neuropathy (LHON are recognized as underlying cause of mitochondrial optic neuropathies ...

Biochemistry and molecular biology

  • 2022 - 2025
    • •
  • 13 769 tis. Kč
    • •
  • 13 769 tis. Kč
    • •
  • MZ
Project

Mitochondria in aging and related diseases ? the role in model organism of Saccharomyces cerevisiae (7AMB12AT001)

processes affecting mitochondrial function and causes of dysfunctions that lead manipulated in genes responsible for mitochondrial morphology (fission, fusion), inthe) construct new mutant strain manipulated in genes of ribosomal c...

EE - Mikrobiologie, virologie

  • 2012 - 2013
    • •
  • 88 tis. Kč
    • •
  • 88 tis. Kč
    • •
  • MŠMT
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